Effect of extra virgin olive oil on inflammatory markers and intestinal microbiota in chronic kidney disease patients.
DOI:
https://doi.org/10.12873/443aliyahKeywords:
Nutrition status, EVOO, CKD, Inflammation, PLR, SCFAAbstract
Introduction : The global prevalence of Chronic Kidney Disease (CKD) is 9.1%, with an increase of 29.3% from 1990 to 2018. A healthy diet with Extra Virgin Olive Oil (EVOO) consumption play a role in reducing inflammation and modulating gut microbiota in CKD patients. This study aims to assess the effect of extra virgin olive oil on immune system platelet-to-lymphocyte ratio (PLR) and Short Chain Fatty Acids (SCFA) in patients with Chronic Kidney Disease (CKD).
Methods: Randomized clinical trial at Dr. Wahidin Sudirohusodo Hospital Makassar on December 2022. The total sample was 30 and divided by two groups , each group both intervention with EVOO 40 ml / day and control group with normal diet (15 patients ). Data were collected through questionnaires and direct measurements for anthropometric (Body weight and Body height). Energy intake with twenty four hours recall. platelet-to-lymphocyte ratio (PLR) through routine blood test and Short chan fatty acids (SCFA) through Pro Healthy Gut tests. Data were analyzed using SPSS version 26 with t-test analysis.
Results: EVOO administration had a significant result on inflammatory markers and gut microbiota. The intervention group had increased energy composition (1370.63±147.76 to 1690.63±147.76; p=0.000) and fat (19.93±7.25 to 57.93±7.25; p=0.000), accompanied by a decrease in Platelet-Lymphocyte Ratio (PLR) (210.76±80.20 to 169.89±54.22; p=0.026) and an increase in Short Chain Fatty Acids (SCFA) in feces (6.86±4.42 to 16.98±15.47; p=0.021) . While the control group showed no significant changes.
Conclusion: Extra virgin olive oil (EVOO) had no significant effect on the nutritional status of patients with Chronic Kidney Disease (CKD) , but reduced inflammation (decreased PLR). In addition improved gut microbiota health (increased SCFA).
References
Shrestha N, Gautam S, Mishra SR, Virani SS, Dhungana RR. Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis. PLoS One. 2021 Oct 14;16(10):e0258494.
Glurich I, Shimpi N, Acharya A. Interdisciplinary care model: chronic kidney disease and oral health. Integration of Medical and Dental Care and Patient Data. 2019:87-107.
Fletcher BR, Damery S, Aiyegbusi OL, Anderson N, Calvert M, Cockwell P, Ferguson J, Horton M, Paap MC, Sidey-Gibbons C, Slade A. Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis. PLoS medicine. 2022 Apr 6;19(4):e1003954.
Ng JK, Li PK. Chronic kidney disease epidemic: how do we deal with it? Nephrology. 2018 Oct;23:116-20.
Ammirati AL. Chronic kidney disease. Revista da Associação Médica Brasileira. 2020 Jan 13;66:s03-9.
Yan MT, Chao CT, Lin SH. Chronic kidney disease: strategies to retard progression. International journal of molecular sciences. 2021 Sep 18;22(18):10084.
Lv JC, Zhang LX. Prevalence and disease burden of chronic kidney disease. Renal fibrosis: mechanisms and therapies. 2019:3-15.
Jones P, Karim Sulaiman S, Gamage KN, Tokas T, Jamnadass E, Somani BK. Do lifestyle factors including smoking, alcohol, and exercise impact your risk of developing kidney stone disease? Outcomes of a systematic review. Journal of endourology. 2021 Jan 1;35(1):1-7.
Schrauben SJ, Apple BJ, Chang AR. Modifiable lifestyle behaviors and CKD progression: a narrative review. Kidney360. 2022 Apr 28;3(4):752-78.
Stern-Zimmer M, Calderon-Margalit R, Skorecki K, Vivante A. Childhood risk factors for adulthood chronic kidney disease. Pediatric Nephrology. 2021 Jun;36(6):1387-96.
Limou S, Vince N, Parsa A. Lessons from CKD-related genetic association studies-moving forward. Clinical journal of the American Society of Nephrology. 2018 Jan 1;13(1):140-52.
Podkowińska A, Formanowicz D. Chronic kidney disease as oxidative stress-and inflammatory-mediated cardiovascular disease. Antioxidants. 2020 Aug 14;9(8):752.
Carney EF. The impact of chronic kidney disease on global health. Nature Reviews Nephrology. May 2020;16(5):251-2.
Elshahat S, Cockwell P, Maxwell AP, Griffin M, O'Brien T, O'Neill C. The impact of chronic kidney disease on developed countries from a health economics perspective: a systematic scoping review. PloS one. 2020 Mar 24;15(3):e0230512.
Gardiner FW, Nwose EU, Bwititi PT, Crockett J, Wang L. Blood glucose and pressure controls in diabetic kidney disease: narrative review of adherence, barriers and evidence of achievement. Journal of Diabetes and its Complications. 2018 Jan 1;32(1):104-12.
Luyckx VA, Cherney DZ, Bello AK. Preventing CKD in developed countries. Kidney international reports. 2020 Mar 1;5(3):263-77.
GBD Chronic Kidney Disease Collaboration. "Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017." The Lancet 395, no. 10225. 2020: 709-733.
Indonesian Ministry of Health. Basic Health Research Results 2018. Ministry of Health. 2018;53(9):1689-99.
Pongsibidang, G., 2016. Risk of Hypertension, Diabetes, and Herbal Drink Consumption on the Incidence of Chronic Kidney Failure at Dr. Wahidin Sudirohusodo Hospital Makassar in 2015. Journal of Wiyata, 3(2), pp.162-167.
Syed-Ahmed M, Narayanan M. Immune dysfunction and risk of infection in chronic kidney disease. Advances in chronic kidney disease. 2019 Jan 1;26(1):8-15.
Thaha M, Widiana IG. The role of inflammation in chronic kidney disease. Indonesian Journal of Kidney and Hypertension. 2019;2(3):4-13.
Li, F., Wang, M., Wang, J., Li, R. and Zhang, Y., 2019. Alterations to the gut microbiota and their correlation with inflammatory factors in chronic kidney disease. Frontiers in Cellular and Infection Microbiology, 9, p.206.
Rysz J, Franczyk B, Ławiński J, Olszewski R, Ciałkowska-Rysz A, Gluba-Brzózka A. The impact of CKD on uremic toxins and gut microbiota. Toxins. 2021 Mar 31;13(4):252.
Mertowska P, Mertowski S, Wojnicka J, Korona-Głowniak I, Grywalska E, Błażewicz A, Załuska W. A link between chronic kidney disease and gut microbiota in immunological and nutritional aspects. Nutrients. 2021 Oct 17;13(10):3637.
Noce A, Marrone G, Urciuoli S, Di Daniele F, Di Lauro M, Pietroboni Zaitseva A, Di Daniele N, Romani A. Usefulness of extra virgin olive oil minor polar compounds in the management of chronic kidney disease patients. Nutrients. 2021 Feb 10;13(2):581.
Marrone G, Urciuoli S, Di Lauro M, Ruzzolini J, Ieri F, Vignolini P, Di Daniele F, Guerriero C, Nediani C, Di Daniele N, Noce A. Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease. Nutrients. 2022 Oct 12;14(20):4265.
López-Novoa JM, Martínez-Salgado C, Rodríguez-Peña AB, Hernández FJ. Common pathophysiological mechanisms of chronic kidney disease: therapeutic perspectives. Pharmacology & therapeutics. 2010 Oct 1;128(1):61-81.
Kandarini Y, SpPD-KGH FI. Nutritional Management in Prialysis and Dialysis CKD Patients. Udayana Repository. 2018.
Hanna RM, Ghobry L, Wassef O, Rhee CM, Kalantar-Zadeh K. A practical approach to nutrition, protein-energy wasting, sarcopenia, and cachexia in patients with chronic kidney disease. Blood purification. 2020 Dec 18;49(1-2):202-11.
Velasquez MT, Centron P, Barrows I, Dwivedi R, Raj DS. Gut microbiota and cardiovascular uremic toxicities. Toxins. 2018 Jul 11;10(7):287.
Qaid MM, Abdelrahman MM. Role of insulin and other related hormones in energy metabolism-A review. Cogent Food & Agriculture. 2016 Dec 31;2(1):1267691.
Sacks FM, Lichtenstein AH, Wu JH, Appel LJ, Creager MA, Kris-Etherton PM, Miller M, Rimm EB, Rudel LL, Robinson JG, Stone NJ. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation. 2017 Jul 18;136(3):e1-23.
Layden BT, Angueira AR, Brodsky M, Durai V, Lowe Jr WL. Short chain fatty acids and their receptors: new metabolic targets. Translational Research. 2013 Mar 1;161(3):131-40.
Liao J, Wei D, Sun C, Yang Y, Wei Y, Liu X. Prognostic value of the combination of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio on mortality in patients on maintenance hemodialysis. BMC nephrology. 2022 Dec 8;23(1):393.
Turkmen K, Erdur FM, Ozcicek F, Ozcicek A, Akbas EM, Ozbicer A, Demirtas L, Turk S, Tonbul HZ. Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients. Hemodialysis International. 2013 Jul;17(3):391-6.
Zhang LY, Zhang J, Li D, Liu Y, Zhang DL, Liu CF, Wang N, Wu SR, Lu WQ, Guo JZ, Shi YQ. Bile reflux is an independent risk factor for precancerous gastric lesions and gastric cancer: An observational cross-sectional study. Journal of Digestive Diseases. 2021 May;22(5):282-90.
Wing MR, Ramezani A, Gill HS, Devaney JM, Raj DS. Epigenetics of progression of chronic kidney disease: fact or fantasy? InSeminars in nephrology 2013 Jul 1 (Vol. 33, No. 4, pp. 363-374). WB Saunders.
Millman JF, Okamoto S, Teruya T, Uema T, Ikematsu S, Shimabukuro M, Masuzaki H. Extra-virgin olive oil and the gut-brain axis: Influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health. Nutrition reviews. 2021 Dec 1;79(12):1362-74.
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