Vitamin D supplementation influences the serum lipid profile in the Jordanian population with vitamin D deficiency
DOI:
https://doi.org/10.12873/Palavras-chave:
Lipid profile; lipoproteins; Vitamin D;Resumo
Purpose: To evaluate the association between vitamin D supplementation and changes in lipid profile in a Jordanian population with vitamin D deficiency.
Methodology: A total of 95 participants, comprising 35 females aged 15-73 years, were recruited for this prospective investigation and administered vitamin D supplements. Blood specimens were examined for lipid profile characteristics and 25(OH)D3 amounts. Vitamin D supplementation protocole involved the weekly dosing of a single tablet containing 50,000 IU of cholecalciferol for the first four weeks, and bi-weekly medication for the final four weeks.
Findings: Before intervention, vitamin D, calcium, total cholesterol, high-density lipoprotein (HDL), decreased lowdensity lipoprotein (LDL), and triglyceride (TG), had no statistical difference between males and females (p=0.231, 0.111, 0.331, 0.821, 0.271, and 0.371, respectively). A noteworthy decrease in serum total cholesterol levels (194±22 mg/dL to 187±19 mg/dL, p<0.05) was noted after vitamin D administration. Although there was a non-significant trend towards LDL cholesterol levels (107±18 mg/dL to 98±15 mg/dL), as well as TG levels (135±26 mg/dL to 128±17 mg/dL), these changes were not statistically significant. Conversely, there was a minor and insignificant rise in the levels of HDL cholesterol (55±13 mg/dL to 57±12 mg/dL). Post intervention, lipid profile parameters correlated positively with vitamin D (r=0.77 for total cholesterol, 0.84 for TG, 0.80 for HDL, and 0.29 for and LDL) with a significant difference (p<0.001, <0.001, <0.001, and 0.004, respectively).
Conclusion: Vitamin D may influence certain aspects of lipid metabolism, but broader conclusions regarding overall lipid profile improvement should be made cautiously.
Referências
References
[1] J. Risteli, W. Winter, M. Kleerekoper, and L. Risteli, "Disorders of bone and mineral metabolism," Tietz Fundamentalis of Clinical Chemistry and Molecular Diagnostics. 7th ed. Bruns: Saunders, pp. 741-68, 2015.
[2] J. Guo, J. A. Lovegrove, and D. I. Givens, "25 (OH) D3-enriched or fortified foods are more efficient at tackling inadequate vitamin D status than vitamin D3," Proceedings of the Nutrition Society, vol. 77, no. 3, pp. 282-291, 2018.
[3] L. Gorman and M. Boosalis, "Nutritional assessment," Clinical chemistry: Techniques, Principles Correlations. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins, pp. 651-72, 2010.
[4] B. Oliveri et al., "Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach," European journal of clinical nutrition, vol. 69, no. 6, pp. 697-702, 2015.
[5] R. Jorde, "The role of vitamin D binding protein, total and free 25-hydroxyvitamin D in diabetes," Frontiers in endocrinology, vol. 10, p. 79, 2019.
[6] M. C. Silva and T. W. Furlanetto, "Intestinal absorption of vitamin D: a systematic review," Nutrition reviews, vol. 76, no. 1, pp. 60-76, 2018.
[7] R. R. Berardi et al., Handbook of nonprescription drugs: an interactive approach to self-care. American Pharmaceutical Association, 2004.
[8] R. Nair and A. Maseeh, "Vitamin D: The “sunshine” vitamin," Journal of pharmacology and pharmacotherapeutics, vol. 3, no. 2, pp. 118-126, 2012.
[9] S. Chirumbolo, G. Bjørklund, A. Sboarina, and A. Vella, "The role of vitamin D in the immune system as a pro-survival molecule," Clinical therapeutics, vol. 39, no. 5, pp. 894-916, 2017.
[10] S. Zhang, D. D. Miller, and W. Li, "Vitamin D in human health," in Essential and Toxic Trace Elements and Vitamins in Human Health: Elsevier, 2020, pp. 263-281.
[11] G. Ferrer-Mayorga, M. J. Larriba, P. Crespo, and A. Muñoz, "Mechanisms of action of vitamin D in colon cancer," The Journal of steroid biochemistry and molecular biology, vol. 185, pp. 1-6, 2019.
[12] C. J. Narvaez, D. Matthews, E. LaPorta, K. M. Simmons, S. Beaudin, and J. Welsh, "The impact of vitamin D in breast cancer: genomics, pathways, metabolism," Frontiers in physiology, vol. 5, p. 213, 2014.
[13] H. V. Stroomberg et al., "Vitamin D levels and the risk of prostate cancer and prostate cancer mortality," Acta Oncologica, vol. 60, no. 3, pp. 316-322, 2021.
[14] P. Jakubowska et al., "Influence of Metabolic Dysregulation in the Management of Depressive Disorder—Narrative Review," Nutrients, vol. 16, no. 11, p. 1665, 2024.
[15] I. Ramasamy, "Vitamin D metabolism and guidelines for vitamin D supplementation," The Clinical Biochemist Reviews, vol. 41, no. 3, p. 103, 2020.
[16] A. Bano et al., "A comparative absorption study of sucrosomial® orodispersible vitamin D3 supplementation vs. a reference chewable tablet and soft gel capsule vitamin D3 in improving circulatory 25 (OH) D levels in healthy adults with vitamin D deficiency—Results from a prospective randomized clinical trial," Frontiers in Nutrition, vol. 10, p. 1221685, 2023.
[17] C. D. L. Marques, A. T. Dantas, T. S. Fragoso, and Â. L. B. P. Duarte, "The importance of vitamin D levels in autoimmune diseases," Revista brasileira de reumatologia, vol. 50, pp. 67-80, 2010.
[18] P. Bordelon, M. V. Ghetu, and R. Langan, "Recognition and management of vitamin D deficiency," American family physician, vol. 80, no. 8, pp. 841-846, 2009.
[19] A. M. Surdu et al., "Vitamin D and its role in the lipid metabolism and the development of atherosclerosis," Biomedicines, vol. 9, no. 2, p. 172, 2021.
[20] V. Schwetz et al., "Vitamin D supplementation and lipoprotein metabolism: a randomized controlled trial," Journal of clinical lipidology, vol. 12, no. 3, pp. 588-596. e4, 2018.
[21] A. Gholamzad, N. Khakpour, T. Kabipour, and M. Gholamzad, "Association between serum vitamin D levels and lipid profiles: a cross-sectional analysis," Scientific reports, vol. 13, no. 1, p. 21058, 2023.
[22] C. Guan et al., "Correlation of serum vitamin D with lipid profiles in middle-aged and elderly Chinese individuals," Asia Pacific Journal of Clinical Nutrition, vol. 29, no. 4, pp. 839-845, 2020.
[23] K. Song et al., "Association of vitamin D status and physical activity with lipid profile in Korean children and adolescents: a population-based study," Children, vol. 7, no. 11, p. 241, 2020.
[24] E. A. Dziedzic, S. Przychodzeń, and M. Dąbrowski, "The effects of vitamin D on severity of coronary artery atherosclerosis and lipid profile of cardiac patients," Archives of medical science, vol. 12, no. 6, pp. 1199-1206, 2016.
[25] J. R. Lupton et al., "Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study," Journal of clinical lipidology, vol. 10, no. 1, pp. 72-81. e1, 2016.
[26] D. Challoumas, "Vitamin D supplementation and lipid profile: what does the best available evidence show?," Atherosclerosis, vol. 235, no. 1, pp. 130-139, 2014.
[27] Y. Wang et al., "The associations of serum lipids with vitamin D status," PloS one, vol. 11, no. 10, p. e0165157, 2016.
[28] A. Manousopoulou, N. M. Al‐Daghri, S. D. Garbis, and G. P. Chrousos, "Vitamin D and cardiovascular risk among adults with obesity: a systematic review and meta‐analysis," European journal of clinical investigation, vol. 45, no. 10, pp. 1113-1126, 2015.
[29] N. Mirhosseini, J. Rainsbury, and S. M. Kimball, "Vitamin D supplementation, serum 25 (OH) D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis," Frontiers in cardiovascular medicine, vol. 5, p. 87, 2018.
[30] S. Kashkooli, R. Choghakhori, A. Hasanvand, and A. Abbasnezhad, "Effect of calcium and vitamin D co-supplementation on lipid profile of overweight/obese subjects: A systematic review and meta-analysis of the randomized clinical trials," Obesity Medicine, vol. 15, p. 100124, 2019.
[31] M. Morvaridzadeh et al., "Effects of calcium and vitamin D co-supplementation on the lipid profile: a systematic review and meta-analysis," Clinical therapeutics, vol. 43, no. 9, pp. 274-296, 2021.
[32] N. Radkhah, M. Zarezadeh, P. Jamilian, and A. Ostadrahimi, "The effect of vitamin D supplementation on lipid profile: an umbrella review of meta-analysis," Advances in Nutrition, 2023.
[33] H. B. Brewer Jr, "New features of the national cholesterol education program adult treatment panel III lipid‐lowering guidelines," Clinical Cardiology: An International Indexed and Peer‐Reviewed Journal for Advances in the Treatment of Cardiovascular Disease, vol. 26, no. S3, pp. 19-24, 2003.
[34] F. Huang et al., "Sex-specific association between serum vitamin D status and lipid profiles: a cross-sectional study of a middle-aged and elderly Chinese population," Journal of Nutritional Science and Vitaminology, vol. 66, no. 2, pp. 105-113, 2020.
[35] A. Yarparvar, I. Elmadfa, A. Djazayery, Z. Abdollahi, and F. Salehi, "The association of vitamin d status with lipid profile and inflammation biomarkers in healthy adolescents," Nutrients, vol. 12, no. 2, p. 590, 2020.
[36] I. Lhilali, N. Zouine, L. Godderis, A. El Midaoui, S. El Jaafari, and Y. Filali-Zegzouti, "Relationship between Vitamin D Insufficiency, Lipid Profile and Atherogenic Indices in Healthy Women Aged 18–50 Years," European Journal of Investigation in Health, Psychology and Education, vol. 14, no. 8, pp. 2337-2357, 2024.
[37] M. F. Raheem, S. H. Ali, and L. G. Shareef, "Impact of serum levels of vitamin D on lipid profiles, glycemic indices, and insulin resistance in obese type 2 diabetes patients: An observational study," F1000Research, vol. 11, no. 1002, p. 1002, 2022.
[38] O. o. D. Supplements, "Dietary supplement fact sheet: vitamin D," ed: National Institutes of Health Bethesda, MD, 2011.
[39] D. C. Muller et al., "No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)," Annals of Oncology, vol. 29, no. 6, pp. 1468-1475, 2018.
[40] V. Hirschler, G. Maccallini, C. Molinari, C. Aranda, and S. A. d. l. C. S. Group, "Low vitamin D concentrations among indigenous Argentinean children living at high altitudes," Pediatric diabetes, vol. 14, no. 3, pp. 203-210, 2013.
[41] S. J. Song et al., "Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size," Public health nutrition, vol. 16, no. 4, pp. 687-692, 2013.
[42] A. Zittermann et al., "Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers," The American journal of clinical nutrition, vol. 89, no. 5, pp. 1321-1327, 2009.
[43] M. R. Kim and S. J. Jeong, "Relationship between vitamin D level and lipid profile in non-obese children," Metabolites, vol. 9, no. 7, p. 125, 2019.
[44] H. Wolden-Kirk, C. Gysemans, A. Verstuyf, and C. Mathieu, "Extraskeletal effects of vitamin D," Endocrinology and metabolism clinics of North America, vol. 41, no. 3, pp. 571-594, 2012.
[45] M. P. Ponda, K. Dowd, D. Finkielstein, P. R. Holt, and J. L. Breslow, "The short-term effects of vitamin D repletion on cholesterol: a randomized, placebo-controlled trial," Arteriosclerosis, thrombosis, and vascular biology, vol. 32, no. 10, pp. 2510-2515, 2012.
[46] D. T. Dibaba, "Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis," Nutrition reviews, vol. 77, no. 12, pp. 890-902, 2019.
[47] R. Scragg et al., "Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial," JAMA cardiology, vol. 2, no. 6, pp. 608-616, 2017.
[48] J. M. Ramiro-Lozano and J. M. Calvo-Romero, "Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency," Therapeutic advances in endocrinology and metabolism, vol. 6, no. 6, pp. 245-248, 2015.
[49] N. M. Al-Daghri et al., "Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study," Cardiovascular diabetology, vol. 11, pp. 1-7, 2012.
[50] M. Barbarawi et al., "Vitamin D supplementation and cardiovascular disease risks in more than 83 000 individuals in 21 randomized clinical trials: a meta-analysis," JAMA cardiology, vol. 4, no. 8, pp. 765-776, 2019.
[51] Y. Yang et al., "Effects of vitamin D supplementation on the regulation of blood lipid levels in prediabetic subjects: A meta-analysis," Frontiers in Nutrition, vol. 10, p. 983515, 2023.
[52] W. Zhang et al., "The effect of vitamin D on the lipid profile as a risk factor for coronary heart disease in postmenopausal women: A meta-analysis and systematic review of randomized controlled trials," Experimental gerontology, vol. 161, p. 111709, 2022.
[53] Q. Lu, Q. Liang, and Y. Xi, "The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials," Frontiers in Nutrition, vol. 11, p. 1419747, 2024.
[54] Y. Li et al., "Association of changes in lipid levels with changes in vitamin D levels in a real-world setting," Scientific reports, vol. 11, no. 1, p. 21536, 2021.
[55] H. Gao, Y. Li, W. Yan, and F. Gao, "The Effect of Vitamin D Supplementation on Blood Lipids in Patients with Polycystic Ovary Syndrome: A Meta‐Analysis of Randomized Controlled Trials," International journal of endocrinology, vol. 2021, no. 1, p. 8849688, 2021.
[56] T. Jafari, A. A. Fallah, and A. Barani, "Effects of vitamin D on serum lipid profile in patients with type 2 diabetes: A meta-analysis of randomized controlled trials," Clinical nutrition, vol. 35, no. 6, pp. 1259-1268, 2016.
Downloads
Publicado
Edição
Seção
Categorias
Licença
Copyright (c) 2025 Nutrición Clínica y Dietética Hospitalaria
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Los lectores pueden utilizar los textos publicados de acuerdo con la definición BOAI (Budapest Open Access Initiative)
