Relationship between inflammatory markers and nutritional status in patients with early-onset Alzheimer's disease (Antioquia-Colombia)
DOI:
https://doi.org/10.12873/443ospinaKeywords:
Alzheimer's disease, Nutritional status, Cytokines, Body mass index, Food safetyAbstract
Background and objectives: Less than 1% of Alzheimer's disease (AD) cases are caused by autosomal dominant E280A presenilin 1 (PSEN1) or presenilin 2 (PSEN2) mutations, which are associated with early onset and accelerated progression of clinical symptoms. Little is known about the relationship between nutritional status and inflammatory markers in this population. The objective of this study was to relate inflammatory markers and nutritional status in patients with early-onset AD with the E280A-PSEN1 mutation.
Material and Methods: cross-sectional study, with a sample of 73 patients with PSEN1 E280A genetic variant, followed by the Antioquia Neuroscience Group (GNA). Sociodemographic information, evaluation of nutritional status by the Mini Nutritional Assessment (MNA), food safety, and measurement of cytokines (IL-6, TNF-α and IFN-γ) by flow cytometry were included. Descriptive statistics, one-way analysis of variance (ANOVA), post-hoc tests, post t-test and Odds Ratio (OR) were applied.
Results: Of the patients evaluated, 64.86% were women and 71.23% were between 36 and 50 years old. According to MNA, 71.62% were classified as at risk of malnutrition and malnutrition; Of these, 59.46% were found in moderate and severe stages of the disease, reporting statistical differences between MNA and cognitive impairment. No statistical differences were found between inflammatory markers with MNA or disease stage. 68.97% of patients at risk of malnutrition were food insecure.
Conclusions: As early-onset AD progresses, the MNA score decreases, increasing malnutrition. In this study, no relationship was found between inflammatory markers and nutritional status. It is essential to continue exploring alternatives that contribute to medical and nutritional management, slowing the progress of the disease, favoring a better quality of life for patients and their families.
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