Relationship between inflammatory markers and nutritional status in patients with early-onset Alzheimer's disease (Antioquia-Colombia)
DOI:
https://doi.org/10.12873/443ospinaKeywords:
Alzheimer's disease, Nutritional status, Cytokines, Body mass index, Food safetyAbstract
Background and objectives: Less than 1% of Alzheimer's disease (AD) cases are caused by autosomal dominant E280A presenilin 1 (PSEN1) or presenilin 2 (PSEN2) mutations, which are associated with early onset and accelerated progression of clinical symptoms. Little is known about the relationship between nutritional status and inflammatory markers in this population. The objective of this study was to relate inflammatory markers and nutritional status in patients with early-onset AD with the E280A-PSEN1 mutation.
Material and Methods: cross-sectional study, with a sample of 73 patients with PSEN1 E280A genetic variant, followed by the Antioquia Neuroscience Group (GNA). Sociodemographic information, evaluation of nutritional status by the Mini Nutritional Assessment (MNA), food safety, and measurement of cytokines (IL-6, TNF-α and IFN-γ) by flow cytometry were included. Descriptive statistics, one-way analysis of variance (ANOVA), post-hoc tests, post t-test and Odds Ratio (OR) were applied.
Results: Of the patients evaluated, 64.86% were women and 71.23% were between 36 and 50 years old. According to MNA, 71.62% were classified as at risk of malnutrition and malnutrition; Of these, 59.46% were found in moderate and severe stages of the disease, reporting statistical differences between MNA and cognitive impairment. No statistical differences were found between inflammatory markers with MNA or disease stage. 68.97% of patients at risk of malnutrition were food insecure.
Conclusions: As early-onset AD progresses, the MNA score decreases, increasing malnutrition. In this study, no relationship was found between inflammatory markers and nutritional status. It is essential to continue exploring alternatives that contribute to medical and nutritional management, slowing the progress of the disease, favoring a better quality of life for patients and their families.
References
Organización Panamericana de la Salud. Trastornos neurológicos: un serio desafío para la salud pública en las Américas y en todo el mundo. 2008. Disponible en: https://www3.paho.org/hq/index.php?option=com_content&view=article&id=240:2008-trastornos-neurologicos-un-serio-desafio-salud-publica-americas-todo mundo&Itemid=40595&lang=es#:~:text=Los%20trastornos%20neurol%C3%B3gicos%20son%20enfermedades,placa%20neuromuscular%2C%20y%20los%20m%C3%BAsculos.
Ministerio de Salud. Grupo Gestión Integrada para la Salud Mental. Boletín de salud mental. Demencia. 2017. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/Boletin-demencia-salud-mental.pdf
Acosta-Baena N, Sepúlveda-Falla D, Lopera-Gómez CM, Jaramillo-Elorza MC, Moreno S, Aguirre-Acevedo DC, et al. Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer’s disease: a retrospective cohort study. Lancet Neurol. 2011; 10(3):213–20.
Gómez VM, García E, Aguillón D, Vélez JE, Jaramillo JE, Vásquez D. Nutritional assessment in patients with early-onset autosomal dominant alzheimer’s disease due to PSEN1- E280A genetic variant: a cross-sectional study. J Aging Res & Lifestyle. 2021; 10:32-8.
Muñoz AM, Agudelo GM, Lopera FJ. Diagnóstico del estado nutricional de los pacientes con demencia tipo Alzheimer registrados en el Grupo de Neurociencias, Medellín, 2004. Biomédica. 2006; 26(1):113-25.
Rivera JA, Mundo V. Inseguridad alimentaria en el hogar y estado de nutrición en personas adultas mayores de México. Salud Pública Méx. 2014; 56(3):71-8.
Tamura B, Masaki K, Blanchette P. Weight loss in patients with Alzheimer’s disease. J Nutr Elder. 2008; 26(3-4):21-38.
Vellas B, Lauque S, Gillette-Guyonnet S, Andrieu S, Cortes F, Nourhashemi F et al. Impact of nutritional status on the evolution of Alzheimer’s disease and on response to acetylcholinesterase inhibitor treatment. J Nutr Health Aging. 2005; 9(2):75-80.
Morales I, Farías, G, Maccioni, R. La neuroinflamación como factor detonante del desarrollo de la enfermedad de Alzheimer. Rev Chil Neuro-Psiquiat. 2010; 48(1):49-57.
Evans DC, Corkins MR, Malone A, Miller S, Mogensen KM, Guenter P, et al. ASPEN Malnutrition Committee. The use of visceral proteins as nutrition markers: an ASPEN position paper. Nutr Clin Pract. 2021; 36(1):22-8.
Volkert D, Chourdakis M, Faxen-Irving G, Frühwald T, Landi F, Suominen MH, et al. ESPEN guidelines on nutrition in dementia. Clin Nutr. 2015; 34(6):1052-73.
Pawelec G, Goldeck D, Derhovanessian E. Inflammation, ageing and chronic disease. Curr Opin Immunol [Internet]. 2014; 29:23-8. Disponible en: http://dx.doi.org/10.1016/j.coi.2014.03.007
Terwee CB, Bot SD, De Boer MR, Van der Windt DA, Knol DL, Dekker J, et al. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol. 2007; 60:34-42.
Rabito EI, Vannucchi GB, Suen VMM, Castilho-Neto LL. Marchini JS. Estimate of weight and height of hospitalized patients. Rev Nutr. 2006; 19:655-61.
Chumlea W C, Guo SS S M. Prediction of stature from knee height for black and white adults and children with application to mobility-impaired or handicapped persons. J Am Diet Assoc. 1994; 94:1385-8.
World Health Organization. El estado físico: uso e interpretación de la antropometría. OMS Serie de Informes Técnicos. 1993. Disponible en: http://whqlibdoc.who.int/trs/WHO_TRS_854_spa.pdf?ua=1
Perú Ministerio de Salud. Guía técnica para la valoración nutricional antropométrica de la persona adulta mayor. 2013. Disponible en: https://bvs.ins.gob.pe/insprint/CENAN/Valoraci%C3%B3n_nutricional_antropom%C3%A9trica_persona_adulta_mayor.pdf
Deossa-Restrepo G C, Restrepo-Betancur L F., Velásquez-Vargas J E, Varela Álvarez D. Evaluación nutricional de adultos mayores con el Mini Nutritional Assessment: MNA. Universidad y Salud. 2016; 18(3): 494-504.
Comité Científico ELCSA. Escala Latinoamericana y Caribeña de Seguridad Alimentaria (ELCSA): manual de uso y aplicaciones. 2012. Disponible en: https://www.fao.org/3/i3065s/i3065s.pdf
Becton, Dickinson and Company. BD Cytometric Bead Array (CBA) Human Soluble Protein Master Buffer Kit. Instruction Manual. 2019. Disponible en: https://www.bdbiosciences.com/content/dam/bdb/marketing-documents/Human-Soluble-Protein-Master-Buffer-Kit-User-Manual.pdf
Izquierdo Delgado E, Gutiérrez Ríos R, Andrés Calvo M, Repiso Gento I, Castrillo Sanz A, Rodríguez Herrero R, et al. Nutritional status assessment in Alzheimer disease and its influence on disease progression. Neurologia (Engl Ed). 2020; S0213-4853(19)30148-3. doi: 10.1016/j.nrl.2019.11.005
Doorduijn AS, de van der Schueren MAE, van de Rest O, de Leeuw FA, Hendriksen HMA, Teunissen CE, et al. Nutritional status is associated with clinical progression in Alzheimer's disease: the NUDAD Project. J Am Med Dir Assoc. 2023; 24(5):638-644.e1. doi: 10.1016/j.jamda.2020.10.020
Beeri MS, Tirosh A, Lin H M, Golan S, Boccara E, Sano M, et al. Stability in BMI over time is associated with a better cognitive trajectory in older adults. Alzheimer's & Dementia. 2022; 18:2131-9.
Martínez R, Estrada F, Hernández A, Barajas A, Islas Escoto S, et al. Neuroinflamación: el ying-yang de la neuroinmunología. Revista Med Inst Mex. 2018; 61(5), 44-53.
Galván M, Rivera A, López G, Hernández J, Gameros Colin M, Morales Sánchez Y, et al. Relationship of food vulnerability with nutritional status and fragility in elderly mexicans. Nutr Clin Diet Hosp. 2019; 39(1):32-9.
Mahieux F, Couderc R, Fénelon G, Maachi M. Amaigrissement et cytokines circulantes chez des patients souffrant d'une maladie d'Alzheimer. Psychol Neuropsychiatr Vieil. 2006; 4(4):281-6.
Fatyga P, Pac A, Fedyk-Łukasik M, Grodzicki T, Skalska A. The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population. Eur Geriatr Med. 2020; 11(3):383-91. doi: 10.1007/s41999-020-00303-4
Namioka N, Hanyu H, Hirose D, Hatanaka H, Sato T, Shimizu S. Oxidative stress and inflammation are associated with physical frailty in patients with Alzheimer's disease. Geriatr Gerontol Int. 2017; 17(6):913-8. doi: 10.1111/ggi.12804
Gubari MIM, Norouzy A, Hosseini M, Mohialdeen FA, Hosseinzadeh-Attar MJ. The Relationship between serum concentrations of pro- and anti-inflammatory cytokines and nutritional status in patients with traumatic head injury in the intensive care unit. Medicina (Kaunas). 2019; 55(8):486. doi: 10.3390/medicina55080486
Sanders CL, Wengreen HJ, Schwartz S, Behrens SJ, Corcoran C, Lyketsos CG, et al. Nutritional status is associated with severe dementia and mortality: the Cache County Dementia Progression Study. Alzheimer Dis Assoc Disord. 2018; 32(4):298-304. doi: 10.1097/WAD.0000000000000274
Pourhassan M, Cederholm T, Trampisch U, Volkert D, Wirth R. Inflammation as a diagnostic criterion in the GLIM definition of malnutrition-what CRP-threshold relates to reduced food intake in older patients with acute disease? Eur J Clin Nutr. 2022; 76(3):397-400. doi: 10.1038/s41430-021-00977-4
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