Effect of Moringa oleifera Lam seed suspension against ethanol-induced neurotoxicity in mice.

Abstract

Objective: To evaluate the effect of Moringa oleifera Lam seed suspension against ethanol-induced neurotoxicity in mice. Methodology: Experimental design study. 35 male mice were used, and seeds of Moringa oleifera Lam (moringa), which were crushed in a mortar with water on each day of the test. The animals were distributed into five groups and received the following treatment for 15 days: group I-II water (10 mL/kg body weight), group III vitamin E (20 IU/kg), group IV moringa seed suspension (200 mg/kg), group V moringa seed suspension (600 mg/kg). Groups II-V were administered 40% ethanol intraperitoneally. At the end of the treatment, the brain and cerebellum were removed for biochemical and histological analyses. The ANOVA test was applied and values ​​that presented p < 0.05 are considered significant. Results: In groups IV-V there will be a tendency to increase the levels of protein sulfhydryl groups (p<0.05) and a decrease in the levels of lipoperoxidation. At the histological level, the conservation of brain and cerebellar tissue will be observed. Conclusion: The administration of Moringa oleifera Lam seed suspension presented a neuroprotective effect expressed in the decrease in lipoperoxidation levels, increase in protein sulfhydryl groups and histological preservation against ethanol-induced toxicity in mice.