Correlación entre marcadores inflamatorios con función física y composición corporal en adultos mayores de la comunidad: estudio transversal.
DOI:
https://doi.org/10.12873/442barrosPalabras clave:
inflamacion, Fuerza Muscular, Composición Corporal, Equilibrio Postural, AncianoResumen
Introducción: El envejecimiento está relacionado con diversas enfermedades crónicas que causan inflamación sistémica, caracterizada por un aumento en los niveles sanguíneos de interleucina 6 (IL-6) y factor de necrosis tumoral alfa (TNF-α). La función física y la composición corporal podrían estar relacionadas con estos marcadores inflamatorios en adultos mayores.
Objetivo: Analizar la correlación entre marcadores inflamatorios sanguíneos, función física y composición corporal en adultos mayores de la comunidad.
Metodología: Estudio transversal con 245 adultos mayores (hombres 68±6 años; mujeres: 69%) de la ciudad de Londrina, Brasil. Se analizaron los niveles sanguíneos de IL-6 y TNF-α con citometría de flujo. Para la evaluación física fue considerado el equilibrio estático con la prueba de estación unipodal (PEU), la fuerza de prensión manual (FPM) utilizando un dinamómetro digital y la capacidad aeróbica con la prueba de caminata de seis minutos (PC6M). Para la evaluación de la composición corporal, fueron considerados los siguientes perímetros: cadera, pantorrilla, cuádriceps, bíceps braquial, tríceps braquial y cintura. Se analizó la correlación de las variables inflamatorias con las de función física y composición corporal, utilizando Pearson o Spearman con el software SPSS versión 22.
Resultados: Los niveles de IL-6 se correlacionaron con la PEU (r: -0.22; p: 0.002), el perímetro de tríceps (r: 0.16; p: 0.023) y el de cintura (r: 0.34; p: 0.000). Los niveles de TNF-α se correlacionaron con FPM (r: -0.15; p: 0.035), el perímetro de tríceps (r: 1.79; p: 0.012) y el de cintura (r: 0.27; p< 0.001).
Conclusión: Los marcadores inflamatorios están relacionados con menor fuerza, equilibrio estático y un aumento en el perímetro de tríceps y cintura en adultos mayores de la comunidad.
Citas
Liu Z, Liang Q, Ren Y, Guo C, Ge X, Wang L, et al. Immuno -
senescence: molecular mechanisms and diseases. Signal Transduct
Target Ther. 2023 May 13;8(1):200.
Bugueño G, Badilla V. Artículo Original Diferencias sobre variables
de salud mental y físico-funcionales entre hombres y mujeres del
primer centro de día referencial del adulto mayor de Chile
Differences on mental and physical-functional health variables
between men and women of the first referential day center of the
older adult of Chile. Nutr clín diet hosp. 2020;40(2):159–64.
Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A.
Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018 Oct 25;14(10):576–90.
Mukai K, Tsai M, Saito H, Galli SJ. Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev. 2018 Mar
;282(1):121–50.
Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, et al.
Redefining Chronic Inflammation in Aging and Age-Related
Diseases: Proposal of the Senoinflammation Concept. Aging Dis.
;10(2):367.
Pothier K, Gana W, Bailly N, Fougère B. Associations Between
Frailty and Inflammation, Physical, and Psycho-Social Health in
Older Adults: A Systematic Review. Front Psychol. 2022 Mar 14;13.
Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S,
Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019 Dec 5;25(12):1822–32.
Sadjapong U, Yodkeeree S, Sungkarat S, Siviroj P. Multicomponent
Exercise Program Reduces Frailty and Inflammatory Biomarkers
and Improves Physical Performance in Community-Dwelling Older
Adults: A Randomized Controlled Trial. Int J Environ Res Public
Health. 2020 May 26;17(11):3760.
El-Mikkawy DME, EL-Sadek MA, EL-Badawy MA, Samaha D.
Circulating level of interleukin-6 in relation to body mass indices
and lipid profile in Egyptian adults with overweight and obesity.
Egyptian Rheumatology and Rehabilitation. 2020 Dec 9;47(1):7.
Reyna-Quiñonez D, Morejón-Iza L, Arteaga-Pazmiño CL. Nutrición
clínica y dietética hospitalaria. Nutrición Clínica y Dietética
Hospitalaria [Internet]. 2020 Aug 22 [cited 2024 Feb 26];43(3).
Available from: https://revista.nutricion.org/index.php/ncdh/
article/view/418
Malta M, Cardoso LO, Bastos FI, Magnanini MMF, da Silva CMFP.
STROBE initiative: guidelines on reporting observational studies.
Rev Saude Publica. 2010;44(3):559–65.
Sepúlveda Loyola WA, Vilaça Cavallari Machado F, Araújo de
Castro L, Hissnauer Leal Baltus T, Rampazzo Morelli N, Landucci, Bonifácio K, et al. Is oxidative stress associated with disease
severity, pulmonary function and metabolic syndrome in chronic
obstructive pulmonary disease? Revista Clínica Española (English
Edition). 2019 Dec;219(9):477–84.
Sánchez-García S, García-Peña C, Duque-López MX, JuárezCedillo T, Cortés-Núñez AR, Reyes-Beaman S. Anthropometric
measures and nutritional status in a healthy elderly population.
BMC Public Health. 2007 Dec 3;7(1):2.
Britto RR, Probst VS, Andrade AFD de, Samora GAR, Hernandes
NA, Marinho PEM, et al. Reference equations for the six-minute
walk distance based on a Brazilian multicenter study. Braz J Phys
Ther. 2013 Dec;17(6):556–63.
Khanal P, He L, Stebbings GK, Onambele-Pearson GL, Degens H,
Williams AG, et al. Static one-leg standing balance test as a
screening tool for low muscle mass in healthy elderly women.
Aging Clin Exp Res. 2021 Jul 13;33(7):1831–9.
Pereira DS, Mateo ECC, de Queiroz BZ, Assumpção AM, Miranda
AS, Felício DC, et al. TNF-α, IL6, and IL10 polymorphisms and the
effect of physical exercise on inflammatory parameters and physical performance in elderly women. Age (Omaha). 2013 Dec
;35(6):2455–63.
Ribeiro JC, Duarte JG, Gomes GAO, Costa-Guarisco LP, de Jesus
ITM, Nascimento CMC, et al. Associations between inflammatory
markers and muscle strength in older adults according to the presence or absence of obesity. Exp Gerontol. 2021 Aug;151:111409.
Bartlett DB, Firth CM, Phillips AC, Moss P, Baylis D, Syddall H, et
al. The age-related increase in low-grade systemic inflammation
(Inflammaging) is not driven by cytomegalovirus infection. Aging
Cell. 2012 Oct 12;11(5):912–5.
Marcos-Pérez D, Sánchez-Flores M, Maseda A, Lorenzo-López L,
Millán-Calenti JC, Gostner JM, et al. Frailty in Older Adults Is
Associated With Plasma Concentrations of Inflammatory Mediators
but Not With Lymphocyte Subpopulations. Front Immunol. 2018
May 16;9.
Zille de Queiroz B, de Britto Rosa NM, Pereira DS, Lopes RA,
Leopoldino AAO, Thomasini RL, et al. Inflammatory mediators
and the risk of falls among older women with acute low back
pain: data from Back Complaints in the Elders (BACE)—Brazil.
European Spine Journal. 2020 Mar 12;29(3):549–55.
Sepúlveda Loyola W, de Barros Morselli J, Araya Quintanilla F,
Teixeira D, Alvarez Bustos A, Molari M, et al. Clinical impact of osteosarcopenia on mortality, physical function and chronic inflammation: a 9-year follow up cohort study. Nutricion Clinica y
Dietetica Hospitalaria [Internet]. 2023 [cited 2024 Feb
;43(4):133–40. Available from: https://researchers.uss.cl/en/
publications/clinical-impact-of-osteosarcopenia-on-mortalityphysical-function
Wu D, Gao X, Shi Y, Wang H, Wang W, Li Y, et al. Association between Handgrip Strength and the Systemic Immune-Inflammation
Index: A Nationwide Study, NHANES 2011–2014. Int J Environ Res
Public Health. 2022 Oct 20;19(20):13616.
De Larichaudy J, Zufferli A, Serra F, Isidori AM, Naro F, Dessalle K,
et al. TNF-α- and tumor-induced skeletal muscle atrophy involves
sphingolipid metabolism. Skelet Muscle. 2012 Dec 18;2(1):2.
Zuo, Prather, Stetskiv, Garrison, Meade, Peace, et al. Inflammaging
and Oxidative Stress in Human Diseases: From Molecular
Mechanisms to Novel Treatments. Int J Mol Sci. 2019 Sep 10;
(18):4472.
Tuttle CSL, Thang LAN, Maier AB. Markers of inflammation and
their association with muscle strength and mass: A systematic review and meta-analysis. Ageing Res Rev. 2020 Dec;64:101185.
Lee SY. Handgrip Strength: An Irreplaceable Indicator of Muscle
Function. Ann Rehabil Med. 2021 Jun 30;45(3):167–9.
Mella De Cuevas KM, Sepúlveda-Loyola W, Araya-Quintanilla F, de
Barros Morselli J, Molari M, Probst VS. Association between clinical measures for the diagnosis of osteosarcopenia with functionality and mortality in older adults: longitudinal study. Nutricion
Clinica y Dietetica Hospitalaria. 2022;42(3):143–51.
Smith L, Yang L, Hamer M. Handgrip strength, inflammatory
markers, and mortality. Scand J Med Sci Sports. 2019 Aug
;29(8):1190–6.
Mella De Cuevas KM, Sepúlveda-Loyola W, Araya-Quintanilla F, de
Barros Morselli J, Molari M, Probst VS. Association between clinical measures for the diagnosis of osteosarcopenia with functionality and mortality in older adults: longitudinal study. Nutricion
Clinica y Dietetica Hospitalaria. 2022;42(3):143–51.
Al-Mansoori L, Al-Jaber H, Prince MS, Elrayess MA. Role of
Inflammatory Cytokines, Growth Factors and Adipokines in
Adipogenesis and Insulin Resistance. Inflammation. 2022 Feb
;45(1):31–44.
Vargas Vitoria R, Alfaro Larena J, Rodríguez M, Arellano R, Valdés
Badilla P. Efectos de un programa multicomponente sobre medidas antropométricas, condición física y calidad de vida relacionada con la salud en personas mayores. Nutricion Clinica y
Dietetica Hospitalaria. 2021 Mar 20;41(1):69–75.
Tay J, Goss AM, Locher JL, Ard JD, Gower BA. Physical Function
and Strength in Relation to Inflammation in Older Adults with
Obesity and Increased Cardiometabolic Risk. J Nutr Health Aging.
Dec 26;23(10):949–57.
Cawthorn WP, Sethi JK. TNF-α and adipocyte biology. FEBS Lett.
Jan 9;582(1):117–31.
Calvani R, Marini F, Cesari M, Buford TW, Manini TM, Pahor M, et
al. Systemic inflammation, body composition, and physical performance in old community-dwellers. J Cachexia Sarcopenia
Muscle. 2017 Feb 8;8(1):69–77.
Tay J, Goss AM, Locher JL, Ard JD, Gower BA. Physical Function
and Strength in Relation to Inflammation in Older Adults with
Obesity and Increased Cardiometabolic Risk. J Nutr Health Aging.
Dec 26;23(10):949–57.
Cesari M, Fielding RA, Pahor M, Goodpaster B, Hellerstein M, Van
Kan GA, et al. Biomarkers of sarcopenia in clinical trials—recommendations from the International Working Group on Sarcopenia.
J Cachexia Sarcopenia Muscle. 2012 Sep 3;3(3):181–90.
Menzel A, Samouda H, Dohet F, Loap S, Ellulu MS, Bohn T. Common
and Novel Markers for Measuring Inflammation and Oxidative Stress
Ex Vivo in Research and Clinical Practice—Which to Use Regarding
Disease Outcomes? Antioxidants. 2021 Mar 9;10(3):414
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