The effect of giving breadfulness leaf drink on High Density Lipoprotein (HDL) in type 2 diabetes mellitus

Muhammad Hisyam Mustamin; Nurhaedar  Jafar; Anna Khuzaimah

doi:10.12873/454hisyam

Autores/as

Muhammad Hisyam Mustamin Hisyam Hasanuddin Universty
Nurhaedar Jafar Hasanuddin University
Anna Khuzaimah Hasanuddin University

DOI:

https://doi.org/10.12873/454hisyam

Palabras clave:

Diabetes Mellitus, HDL, Breadfruit Leaves

Resumen

Background: Diabetes is one of the leading causes of death and affects many people regardless of country, age group, and gender. According to Riskesdas data, the prevalence of diabetes mellitus is increasing every year, so efforts are needed to address this issue. Sukun leaves and cinnamon contain antioxidant compounds that can improve lipid dysfunction. This study aims to assess the effect of sukun leaf drink on High Density Lipoprotein (HDL) levels in diabetes mellitus cases. Method: This study is a quasi-experimental study with a randomised pretest-posttest design with a control group. The total sample size was 40 people. The variable in this study was High-Density Lipoprotein (HDL). The intervention group was given breadfruit leaf drink with cinnamon and education, while the control group was only given education. The intervention was carried out for 30 days. Data were analysed using the paired t-test and Wilcoxon Rank Test.

Results: The results of HDL level analysis in the intervention group were 47.95 pretest and 58.68 posttest (p value = 0.003), while in the control group they were 47.19 pretest and 52.24 posttest (p value = 0.013). Conclusion: There was an increase in High Density Lipoprotein (HDL) levels in both the group given the drink and the group not given the breadfruit leaf drink, but the increase was higher in the group given the breadfruit leaf drink. Further research is recommended to add physical activity to accurately identify factors contributing to GDP reduction in diabetes mellitus.

Referencias

[1] Agustina, M. (2017). CORRELATION BETWEEN DIETARY PATTERN OF PATIENTS WITH TYPE 2 DIABETES MELLITUS AND BLOOD SUGAR LEVEL. Proceedings of the International Conference on Applied Science and Health, 331–336.

[2] Arifin, B., & Ibrahim, S. (2018). Structure, Bioactivity, Antioxidants, and Flavonoids. Jurnal Zarah, 6(1), 21–29. https://doi.org/10.31629/zarah.v6i1.313 DOI: https://doi.org/10.31629/zarah.v6i1.313

[3] Bays, H. E. (2023). Why does type 2 diabetes mellitus impair weight reduction in patients with obesity? A review. Obesity Pillars, 7, 100076. https://doi.org/10.1016/j.obpill.2023.100076 DOI: https://doi.org/10.1016/j.obpill.2023.100076

[4] Bindu Jacob, & Narendhirakannan R.T. (2019). Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech, 9(1), 4. https://doi.org/10.1007/s13205-018-1528-0 DOI: https://doi.org/10.1007/s13205-018-1528-0

[5] Dal Canto, E., Ceriello, A., Rydén, L., Ferrini, M., Hansen, T. B., Schnell, O., Standl, E., & Beulens, J. W. J. (2019). Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. European Journal of Preventive Cardiology, 26(2_suppl), 25–32. https://doi.org/10.1177/2047487319878371 DOI: https://doi.org/10.1177/2047487319878371

[6] Sukun Leaf (Artocarpus Altilis) in Type II Diabetes Mice Induced by Fructose. www.stikescendekiautamakudus.ac.id

[7] Femlak, M., Gluba-Brzózka, A., Ciałkowska-Rysz, A., & Rysz, J. (2017). The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk. Lipids in Health and Disease, 16(1), 207. https://doi.org/10.1186/s12944- 017-0594-3 DOI: https://doi.org/10.1186/s12944-017-0594-3

[8] Junaedi, S. (2021). The Effect of Breadfruit Leaf Extract on Fasting Blood Glucose and Lipid Profile in Prediabetic Patients in Maros Regency.

[9] Ministry of Health. (2023). National Health Survey 2023.

[10] Lathifah, N. L. (2017). The Relationship Between Disease Duration and Blood Sugar Levels with Subjective Complaints in Diabetes Mellitus Patients. 5, 231–239. https://doi.org/10.20473/jbe.v5i2.2017.231-239 DOI: https://doi.org/10.20473/jbe.V5I22017.218-230

[11] Lengkey, Y. K. (2022). Testing the Antidiabetic Activity of Breadfruit Leaf (Artocarpus altilis) Infusion in White Rats (Rattus norvegicus) Induced by Alloxan. Info Sains Magazine, 2022(1), 7–14. DOI: https://doi.org/10.55724/jis.v3i1.43

[12] Luo, J., Ning, T., Li, X., Jiang, T., Tan, S., & Ma, D. (2024). Targeting IL-12 family cytokines: A potential strategy for type 1 and type 2 diabetes mellitus. In Biomedicine and Pharmacotherapy (Vol. 170). Elsevier Masson s.r.l. https://doi.org/10.1016/j.biopha.2023.115958 DOI: https://doi.org/10.1016/j.biopha.2023.115958

[13] Merliana Anna, & Islamiyati Ricka. (2017). Antidiabetic activity test of ethanol extract

[14] Ong, K. L., Stafford, L. K., Mclaughlin, S. A., Boyko, E. J., Vollset, S. E., Smith, A. E., Dalton, B. E., Duprey, J., Cruz, J. A., Hagins, H., Lindstedt, P. A., Aali, A., Abate, Y. H., Abate, M. D., Abbasian, M., Abbasi-Kangevari, Z., Abbasi-Kangevari, M., Elhafeez, S. A., Abd-Rabu, R., ... Vos, T. (2023). Global, Regional, and National Burden of Diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet, 402(10397), 203–234. https://doi.org/10.1016/S0140-6736(23)01301-6 DOI: https://doi.org/10.1016/S0140-6736(23)01301-6

[15] Rafsanjani, M. S., Asriati, A., Kholidha, A. N., & Alifariki, L. O. (2019). The Relationship Between High-Density Lipoprotein (HDL) Levels and Hypertension. Jurnal Profesi Medika: Journal of Medicine and Health, 13(2).

[16] https://doi.org/10.33533/jpm.v13i2.1274 DOI: https://doi.org/10.33533/jpm.v13i2.1274

[17] Silalahi, M. (2021). Utilisation of Breadfruit (Artocarpus altilis) as Traditional Medicine and Alternative Food Ingredient (Vol. 4, Issue 1).

[18] Song, J., Kwon, O., Chen, S., Daruwala, R., Eck, P., Park, J. B., & Levine, M. (2002). Flavonoid Inhibition of Sodium-dependent Vitamin C Transporter 1 (SVCT1) and Glucose Transporter Isoform 2 (GLUT2), Intestinal Transporters for Vitamin C and Glucose. Journal of Biological Chemistry, 277(18), 15252–15260. https://doi.org/10.1074/jbc.M110496200 DOI: https://doi.org/10.1074/jbc.M110496200

[19] Tevlin, R., Seo, E. Y., Marecic, O., McArdle, A., Tong, X., Zimdahl, B., Malkovskiy, A., Sinha, R., Gulati, G., Li, X., Wearda, T., Morganti, R., Lopez, M., Ransom, R. C., Duldulao, C. R., Rodrigues, M., Nguyen, A., Januszyk, M., Maan, Z., ... Longaker, M. T. (2017). Pharmacological rescue of diabetic skeletal stem cell niches. Science Translational Medicine, 9(372). https://doi.org/10.1126/scitranslmed.aag2809 DOI: https://doi.org/10.1126/scitranslmed.aag2809

[20] ZA, M. A. N. H., Sri Wahyuni Gayatri, Sigit Dwi Pramono, Prema Hapsari Hidayati, & Syamsu, R. F. (2022). The relationship between dyslipidaemia and type 2 diabetes mellitus at Ibnu Sina Hospital, Makassar. Fakumi Medical Journal: Journal of Medical Students, 2(9), 668–677. https://doi.org/10.33096/fmj.v2i9.122 ` DOI: https://doi.org/10.33096/fmj.v2i9.122