Polimorfismo del gen GHSR asociado con un menor puntaje Z de peso para la edad
DOI:
https://doi.org/10.12873/Palabras clave:
GHSR, Desnutrición, Niños menores de cinco años, Bajo pesoResumen
La desnutrición sigue siendo un importante problema de salud pública, con esfuerzos continuos para identificar estrategias efectivas para su prevención. Sin embargo, los factores genéticos que influyen en el crecimiento infantil, particularmente el papel del gen GHSR, no han sido suficientemente explorados. Este estudio tuvo como objetivo investigar la correlación entre los polimorfismos del gen GHSR y los puntajes Z de peso para la edad (WAZ) en niños de Java Occidental, Indonesia. Se realizó un estudio transversal con 110 niños de entre 12 y 59 meses de edad. Se tomaron mediciones de peso para calcular el WAZ y la ingesta dietética se evaluó mediante un recordatorio alimentario de 24 horas. Se recolectaron muestras de sangre para la extracción de plasma y se realizó un análisis de SNP del gen GHSR utilizando RT-PCR. El estudio reveló una alta prevalencia de bajo peso entre los niños, con un 41,8% clasificado como bajo peso. Se encontró una asociación significativa entre el genotipo TT del polimorfismo GHSR G57G y un menor WAZ en comparación con los genotipos CC y CT. Esto sugiere que los polimorfismos del gen GHSR pueden desempeñar un papel en la desnutrición, específicamente en la influencia sobre el desarrollo del peso. Estos hallazgos resaltan la posible influencia de los polimorfismos del gen GHSR en el estado nutricional y el crecimiento infantil. Se necesita más investigación para explorar los factores genéticos que contribuyen a la desnutrición y desarrollar intervenciones específicas para mejorar los resultados de salud infantil.
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Derechos de autor 2025 Nutrición Clínica y Dietética Hospitalaria
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