Correlation between physical activity in older adults and markers of oxidative stress and antioxidant capacity
DOI:
https://doi.org/10.12873/444sepulvedaKeywords:
Actividad Fisica, anciano, adulto mayor, actividad antioxidante, Estrés OxidativoAbstract
Introduction: In the aging process, the balance between protein production by reactive oxygen species and antioxidant capacity becomes destabilized, leading to cellular and molecular aging. However, physical activity can improve antioxidant capacity and reduce oxidative stress.
Objective: To analyze the correlation between physical activity and oxidative and antioxidant markers in community-dwelling older adults.
Method: A cross-sectional study was conducted with 34 community-dwelling older adults (57% male, mean age 69±6 years). Physical activity variables (number of steps, time spent on various activities, total energy expenditure) were assessed using an accelerometer. Additionally, antioxidant markers (SOD, PON1, CAT, and SH) and oxidative markers (NOX, LOOH, and AOPP) in blood samples taken after 10 hours of fasting were analyzed.
Results: The number of steps was correlated with higher levels of antioxidants SOD (p: 0.006) and CAT (p: 0.018); time spent on light-intensity activities was associated with lower levels of PON1 (p: 0.01); total energy expenditure correlated with levels of SOD (p: 0.001) and SH (p: 0.011); and time spent on vigorous physical activity was associated with levels of NOX (p: 0.03). Associations were observed between the number of steps and levels of CAT (beta coefficient [5.7; 95% CI: 0.8-10.6] x 10^5; p: 0.024) and SOD (beta coefficient [8.7; 95% CI: 2.7-14.8] x 10^5; p: 0.006). Time spent on light-intensity activities (1.5 METs) was associated with PON1 (beta coefficient [-1.9; 95% CI: -3.9 to -0.1] x 10^4; p: 0.006).
Conclusions: There is a correlation between physical activity and oxidative and antioxidant markers in community-dwelling older adults. The number of steps and the time spent on physical activities are the main variables associated with oxidative stress markers.
References
Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Sig Transduct Target Ther. 16 de diciembre de 2022;7(1):391.
Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. septiembre de 2021;20(9):689-709.
El Assar M, Álvarez-Bustos A, Sosa P, Angulo J, Rodríguez-Mañas L. Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging. International Journal of Molecular Sciences. 2022;23(15).
Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. Oxidative stress, aging, and diseases. CIA. abril de 2018; Volume 13:757-72.
Barros-Osorio C, Sepulveda-Loyola W, Astudillo I, Campos-Aguayo J, Valenzuela- Fuenzalida JJ, Suziane Probst V. Correlación entre marcadores inflamatorios con función física y composición corporal en adultos mayores de la comunidad: estudio transversal. Nutr Clín Diet Hosp [Internet]. 22 de abril de 2024 [citado 16 de agosto de 2024];44(2). Disponible en: https://revista.nutricion.org/index.php/ncdh/article/view/558
Liu Y, Wang Y, Yao N, Sun M, Guo R, Wang F, et al. Interaction between composite dietary antioxidant index and physical activity on cognitive impairment in the elderly: NHANES 2011–2014. Journal of Functional Foods. 1 de enero de 2024;112:105945.
Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. diciembre de 2020;54(24):1451-62.
Tompuri TT. Metabolic equivalents of task are confounded by adiposity, which disturbs objective measurement of physical activity. Front Physiol [Internet]. 11 de agosto de 2015 [citado 18 de junio de 2024];6. Disponible en: http://journal.frontiersin.org/Article/10.3389/fphys.2015.00226/abstract
Organización mundial de la salud. Actividad física. OMS. 2024. Accedido el 30 de Mayo de 2024. https://www.who.int/es/newsroom/fact-sheets/detail/physical-activity
Tudor-Locke C, Han H, Aguiar EJ, Barreira TV, Schuna Jr JM, Kang M, et al. How fast is fast enough? Walking cadence (steps/min) as a practical estimate of intensity in adults: a narrative review. Br J Sports Med. junio de 2018;52(12):776-88.
Ostendorf DM, Caldwell AE, Creasy SA, Pan Z, Lyden K, Bergouignan A, et al. Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers. Obesity. marzo de 2019;27(3):496-504.
Cordeiro Maluf J, Sepúlveda-Loyola W, Tricanico Maciel RP, Carvalho G, Pereira PS, Suziane Probst V. Correlación entre actividad física en la vida diaria y biomarcadores de estrés oxidativo y metabólicos en adultos mayores. Rev Medicas UIS. 10 de mayo de 2020;33(1):13-9.
Kawamura T, Muraoka I. Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants. 5 de septiembre de 2018;7(9):119.
Fernández JM, Fuentes-Jiménez F, López-Miranda J. Función endotelial y ejercicio físico. Revista Andaluza de Medicina del Deporte. 2009;2(2):61-9.
Traustadóttir T, Davies SS, Su Y, Choi L, Brown-Borg HM, Roberts LJ, et al. Oxidative stress in older adults: effects of physical fitness. AGE. agosto de 2012;34(4):969-82.
Fokkenrood HJP, Verhofstad N, van den Houten MML, Lauret GJ, Wittens C, Scheltinga MRM, et al. Physical Activity Monitoring in Patients with Peripheral Arterial Disease: Validation of an Activity Monitor. European Journal of Vascular and Endovascular Surgery. 1 de agosto de 2014;48(2):194-200.
Yao J, Tan CS, Lim N, Tan J, Chen C, Müller-Riemenschneider F. Number of daily measurements needed to estimate habitual step count levels using wrist-worn trackers and smartphones in 212,048 adults. Sci Rep. 5 de mayo de 2021;11(1):9633.
Kraus WE, Janz KF, Powell KE, Campbell WW, Jakicic JM, Troiano RP, et al. Daily Step Counts for Measuring Physical Activity Exposure and Its Relation to Health. Medicine & Science in Sports & Exercise. junio de 2019;51(6):1206-12.
Shibukawa T, Fujiyoshi A, Moniruzzaman M, Miyagawa N, Kadota A, Kondo K, et al. Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men. Preventive Medicine Reports. febrero de 2024;38:102615.
Master H, Annis J, Huang S, Beckman JA, Ratsimbazafy F, Marginean K, et al. Association of step counts over time with the risk of chronic disease in the All of Us Research Program. Nat Med. noviembre de 2022;28(11):2301-8.
Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, et al. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. 30 de marzo de 2018;9(24):17181-98.
Powers SK, Goldstein E, Schrager M, Ji LL. Exercise Training and Skeletal Muscle Antioxidant Enzymes: An Update. Antioxidants. 25 de diciembre de 2022;12(1):39.
Ściskalska M, Ołdakowska M, Marek G, Milnerowicz H. Changes in the Activity and Concentration of Superoxide Dismutase Isoenzymes (Cu/Zn SOD, MnSOD) in the Blood of Healthy Subjects and Patients with Acute Pancreatitis. Antioxidants. 1 de octubre de 2020;9(10):948.
Nandi A, Yan LJ, Jana CK, Das N. Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases. Oxidative Medicine and Cellular Longevity. 11 de noviembre de 2019;2019:1-19.
Lin CH, Li TM, Huang YJ, Chen SJ, Lane HY. Differential Impacts of Endogenous Antioxidants on Clinical Symptoms and Cognitive Function in Acute and Chronic Schizophrenia Patients. International Journal of Neuropsychopharmacology. 1 de agosto de 2023;26(8):576-83.
Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, et al. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front Physiol. 2 de julio de 2020;11:694.
Vona R, Pallotta L, Cappelletti M, Severi C, Matarrese P. The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders. Antioxidants. 30 de enero de 2021;10(2):201.
Jarrete AP, Novais IP, Nunes HA, Puga GM, Delbin MA, Zanesco A. Influence of aerobic exercise training on cardiovascular and endocrine-inflammatory biomarkers in hypertensive postmenopausal women. Journal of Clinical & Translational Endocrinology. septiembre de 2014;1(3):108-14.
Fraile-Bermúdez AB, Kortajarena M, Zarrazquin I, Maquibar A, Yanguas JJ, Sánchez-Fernández CE, et al. Relationship between physical activity and markers of oxidative stress in independent community-living elderly individuals. Experimental Gerontology. 1 de octubre de 2015;70:26-31.
de Sousa CV, Sales MM, Rosa TS, Lewis JE, de Andrade RV, Simões HG. The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis. Sports Medicine. 1 de febrero de 2017;47(2):277-93.
Rosado-Pérez J, Santiago-Osorio E, Ortiz R, Mendoza-Núñez VM. Tai Chi diminishes oxidative stress in Mexican older adults. The Journal of nutrition, health and aging. agosto de 2012;16(7):642-6.
Nyberg M, Blackwell JR, Damsgaard R, Jones AM, Hellsten Y, Mortensen SP. Lifelong physical activity prevents an age‐related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans. The Journal of Physiology. noviembre de 2012;590(21):5361-70.
Dostálová R, Stillman C, Erickson KI, Slepička P, Mudrák J. The Relationship between Physical Activity, Self-Perceived Health, and Cognitive Function in Older Adults. Brain Sciences. 13 de abril de 2021;11(4):492.
Meng Q, Su CH. The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks. Antioxidants. 7 de mayo de 2024;13(5):573.
Van Niekerk E, Botha Le Roux S, Atzler D, Schwedhelm E, Böger RH, Van Rooyen JM, et al. Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study. J Hum Hypertens. abril de 2021;35(4):325-33.
Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, et al. Physical Activity Prevents Age-Related Impairment in Nitric Oxide Availability in Elderly Athletes. Circulation. 27 de junio de 2000;101(25):2896-901.
Vargas-Mendoza N, Angeles-Valencia M, Morales-González Á, Madrigal-Santillán EO, Morales-Martínez M, Madrigal-Bujaidar E, et al. Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition. Life. 22 de noviembre de 2021;11(11):1269.
Arefirad T, Seif E, Sepidarkish M, Mohammadian Khonsari N, Mousavifar SA, Yazdani S, et al. Effect of exercise training on nitric oxide and nitrate/nitrite (NOx) production: A systematic review and meta-analysis. Frontiers in Physiology [Internet]. 2022;13. Disponible en: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.953912
Garavaglia, M. L., Giustarini, D., Colombo, G., Reggiani, F., Finazzi, S., Calatroni, M., Landoni, L., Portinaro, N. M., Milzani, A., Badalamenti, S., Rossi, R., & Dalle-Donne, I. Blood Thiol Redox State in Chronic Kidney Disease. International journal of molecular sciences. 2022; 23(5), 2853. https://doi.org/10.3390/ijms23052853
Lepedda A, and Formato M. Oxidative Modifications in Advanced Atherosclerotic Plaques: A Focus on In Situ Protein Sulfhydryl Group Oxidation. Oxidative Modifications in Advanced Atherosclerotic Plaques. 2020; 2020(1). https://doi.org/10.1155/2020/6169825 01-07
Liqin Q, Ruonan G, Zhou C, Donghai L, Zhiqing Q, Linxi W, et al. Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells. NeuroToxicology. 2022; 92, 166-179. https://doi.org/10.1016/j.neuro.2022.08.007
Li N, Ye Q, Deng Q, Wang Y, Hu J, Li X, et al. Physical Activity Intervention for Leisure-Time Activity Levels Among Older Adults: A Cluster Randomized Trial. JAMA Network Open. 15 de septiembre de 2023;6(9):e2333195-e2333195.
Blackburn NE, Skjodt M, Tully MA, Mc Mullan I, Giné-Garriga M, Caserotti P, et al. Older Adults’ Experiences of a Physical Activity and Sedentary Behaviour Intervention: A Nested Qualitative Study in the SITLESS Multi-Country Randomised Clinical Trial. International Journal of Environmental Research and Public Health. 2021;18(9).
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