Correlation between physical activity in older adults and markers of oxidative stress and antioxidant capacity

Authors

  • Victoria Sotomayor
  • Vanessa Suziane Probst
  • Óscar Pizarro Salazar
  • Walter Sepulveda Loyola aculty of Health and Social Sciences, Universidad de Las Americas, Santiago, Chile

DOI:

https://doi.org/10.12873/444sepulveda

Keywords:

Actividad Fisica, anciano, adulto mayor, actividad antioxidante, Estrés Oxidativo

Abstract

Introduction: In the aging process, the balance between protein production by reactive oxygen species and antioxidant capacity becomes destabilized, leading to cellular and molecular aging. However, physical activity can improve antioxidant capacity and reduce oxidative stress.

Objective: To analyze the correlation between physical activity and oxidative and antioxidant markers in community-dwelling older adults.

Method: A cross-sectional study was conducted with 34 community-dwelling older adults (57% male, mean age 69±6 years). Physical activity variables (number of steps, time spent on various activities, total energy expenditure) were assessed using an accelerometer. Additionally, antioxidant markers (SOD, PON1, CAT, and SH) and oxidative markers (NOX, LOOH, and AOPP) in blood samples taken after 10 hours of fasting were analyzed.

Results: The number of steps was correlated with higher levels of antioxidants SOD (p: 0.006) and CAT (p: 0.018); time spent on light-intensity activities was associated with lower levels of PON1 (p: 0.01); total energy expenditure correlated with levels of SOD (p: 0.001) and SH (p: 0.011); and time spent on vigorous physical activity was associated with levels of NOX (p: 0.03). Associations were observed between the number of steps and levels of CAT (beta coefficient [5.7; 95% CI: 0.8-10.6] x 10^5; p: 0.024) and SOD (beta coefficient [8.7; 95% CI: 2.7-14.8] x 10^5; p: 0.006). Time spent on light-intensity activities (1.5 METs) was associated with PON1 (beta coefficient [-1.9; 95% CI: -3.9 to -0.1] x 10^4; p: 0.006).

Conclusions: There is a correlation between physical activity and oxidative and antioxidant markers in community-dwelling older adults. The number of steps and the time spent on physical activities are the main variables associated with oxidative stress markers.

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Published

2024-10-23

How to Cite

Sotomayor, V., Probst, V. S., Pizarro Salazar, Óscar, & Sepulveda Loyola, W. (2024). Correlation between physical activity in older adults and markers of oxidative stress and antioxidant capacity . Nutrición Clínica Y Dietética Hospitalaria, 44(4). https://doi.org/10.12873/444sepulveda

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