Association of major depressive disorder (MDD) with zinc levels and handgrip muscle strength in a sample of Colombian adults.
DOI:
https://doi.org/10.12873/441castanoKeywords:
zinc, handgrip Strength, Depressive Disorder, Diet, clinical nutritionAbstract
Introduction: Depression is related with poor muscle strength, and deficiencies of microelements such as zinc (Zn). Otherwise, Zn is related with muscle strength, but there is no evidence of the relations between muscle strength and Zn levels in depression.
Objective: To determine the association between serum Zn levels, muscle strength, and depression.
Methods: An observational, analytical case-control study. 103 depressive patients hospitalized at the San Juan de Dios Clinic in Manizales, and 36 controls with no personal history of mental illness were evaluated for depression severity, serum zinc levels (Zn), and handgrip strength. The groups were matched by sex, age, educational level, and socioeconomic stratum. The severity of depression was assessed using the Montgomery–Asberg Rating Scale (MADRS). Serum Zn levels were determined, and handgrip strength was assessed using dynamometer. Descriptive analysis, logistic regression and linear models were performed with depression and severity of depression as dependent variables.
Results: Lower Zn levels and reduced handgrip strength were related to the presence of depression with the logistic model. Lower handgrip strength and severity of depression were associated with the linear model.
Conclusion: An association was found between depression and low Zn levels, and an inverse association between severity of depression and muscle strength. Future studies should investigate causality, and to evaluate the relationship between depression, muscle strength and nutritional status.
References
Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder. JAMA. 2003;289(4):3097–105.
Uchida S, Yamagata H, Seki T, Watanabe Y. Epigenetic mechanisms of major depression: Targeting neuronal plasticity. Psychiatry Clin Neurosci. 2018;72(4):212–27.
Anbari-Nogyni Z, Bidaki R, Madadizadeh F, Sangsefidi ZS, Fallahzadeh H, Karimi-Nazari E, Nadjarzadeh A. Relationship of Zinc status with depression and anxiety among elderly population. Clin Nutr ESPEN. 2020 Jun;37:233-239.
Jackson MJ, Jones DA, Edwards RHT. Tissue Zinc levels as an index of body Zinc status. Clin Physiol. 1982;2(4):333–43.
Uher R, Tansey KE, Dew T, Maier W, Mors O, Hauser J, et al. An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline. Am J Psychiatry. 2014;171(12):1278–86.
Maes M, De Vos N, Demedts P, Wauters A, Neels H. Lower serum Zinc in major depression in relation to changes in serum acute phase proteins. J Affect Disord. 1999;56(2–3):189–94.
Styczeń K, Sowa-Kućma M, Siwek M, Dudek D, Reczyński W, Szewczyk B, et al. The serum Zinc concentration as a potential biological marker in patients with major depressive disorder. Metab Brain Dis. 2017;32(1):97–103.
Gonoodi K, Moslem A, Ahmadnezhad M, Darroudi S, Mazloum Z, Tayefi M, et al. Relationship of Dietary and Serum Zinc with Depression Score in Iranian Adolescent Girls. Biol Trace Elem Res. 2018;186(1):91–7.
Hernández-Camacho JD, Vicente-García C, Parsons DS, NavasEnamorado I. Zinc at the crossroads of exercise and proteostasis. Redox Biol [Internet]. 2020;35(January):101529.
Zasadzka E, Pieczy´nska A, Pieczy´nska P, Trzmiel T, Kleka P, Pawlaczyk M, et al. Correlation between Handgrip Strength and Depression in Older Adults-A Systematic Review and a MetaAnalysis. Public Health. 2021;18:4823.
van Dronkelaar C, van Velzen A, Abdelrazek M, van der Steen A, Weijs PJM, Tieland M. Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical
Performance in Older Adults: A Systematic Review. J Am Med Dir Assoc [Internet]. 2018;19(1):6-11.e3.
Lee JM, Ryan EJ. The relationship between muscular strength and depression in older adults with chronic disease comorbidity. Int J Environ Res Public Health [Internet]. 2020;17(18):1–10.
Fukumori N, Yamamoto Y, Takegami M, Yamazaki S, Onishi Y, Sekiguchi M, et al. Association between hand-grip strength and depressive symptoms: Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS). Age Ageing. 2015; 44(4):592–8.
Han KM, Chang J, Yoon HK, Ko YH, Ham BJ, Kim YK, et al. Relationships between hand-grip strength, socioeconomic status, and depressive symptoms in community-dwelling older adults. J Affect Disord. 2019;252(November 2018):263–70.
Alvarez-Galvez J, Gomez-Baya D. Socioeconomic context as a moderator in the relationship between body mass index and depression in Europe. Appl Psychol Heal Well-Being. 2017;9(3):410–28.
World Medical Association. WMA Declaration of Helsinki: ethical principles for medical research involving human subjects. 1974;353(1):1418–9. Available from: http://www.wma.net/en/ 30publications/10policies/b3/index.html.
Lobo A, Chamorro L, Luque A, Dal-Ré R, Badia X, Baró E. Validación de las versiones en español de la Montgomery-Asberg Depression Rating Scale y la Hamilton Anxiety Rating Scale para la evaluación de la depresión y de la ansiedad. Med Clin (Barc) [Internet]. 2002;118(13):493–9. Available from: https://www.elsevier.es/es-revista-medicina-clinica-2-articulo-validacion-versiones-espanol-montgomery-asberg-depression-13029223
Cronin J, Lawton T, Harris N, Kilding A, McMaster DT. A brief review of handgrip strength and sport performance. Vol. 31, Journal of Strength and Conditioning Research. 2017. 3187–3217 p.
Li Z, Li B, Song X, Zhang D. Dietary Zinc and iron intake and risk of depression: A meta-analysis. Psychiatry Res [Internet]. 2017; 251:41–7.
Brooks JM, Titus AJ, Bruce ML, Orzechowski NM, Mackenzie TA, Bartels SJ, et al. Depression and handgrip strength among U.S. adults aged 60 years and older from nhanes. J NutrHealAging. 2018;22(8):938–43.
Marques A, Gomez-Baya D, Peralta M, Frasquilho D, Santos T, Martins J, et al. The effect of muscular strength on depression symptoms in adults: A systematic review and meta-analysis. Int J Environ Res Public Health. 2020;17(16):1–13.
Lönnerdal B. Dietary factors influencing Zinc absorption. J Nutr. 2000;130(5 Suppl).
Lukaski HC. Low dietary Zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise. Am J Clin Nutr. 2005;81(5):1045–51.
Maserejian NN, Hall SA, McKinlay JB. Low dietary or supplemental Zinc is associated with depression symptoms among women, but not men, in a population-based epidemiological survey. J Affect Disord [Internet]. 2012;23(1):1–7.
DSM-5 Diagnostic and Statistical Manual of Mental Disorders. Arlington: American Psychiatric Association; 2013.
Olechnowicz J, Tinkov • A, Skalny • A, Suliburska J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. J Physiol Sci [Internet]. 2018;68(1):19–13.
Twayej AJ, Al-Hakeim HK, Al- Dujaili AH, Maes M. Lowered Zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation. World J Biol Psychiatry [Internet]. 2020;21(2):127–38.
Krotkiewski M, Gudmundsson M, Backström P, Mandroukas K. Zinc and muscle strength and endurance. Acta Physiol Scand. 1982;116(3):309–11.
Wang J, Um P, Dickerman BA, Liu J. Zinc, magnesium, selenium and depression: A review of the evidence, potential mechanisms and implications. Nutrients. 2018;10(5).
Maes M, Vandoolaeghe E, Neels H, Demedts P, Wauters A, Meltzer HY, et al. Lower serum Zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness. Biol Psychiatry. 1997;42(5):349–58.
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