Association of major depressive disorder (MDD) with zinc levels and handgrip muscle strength in a sample of Colombian adults.
DOI:
https://doi.org/10.12873/441castanoPalavras-chave:
zinc, handgrip Strength, Depressive Disorder, Diet, clinical nutritionResumo
Introduction: Depression is related with poor muscle strength, and deficiencies of microelements such as zinc (Zn). Otherwise, Zn is related with muscle strength, but there is no evidence of the relations between muscle strength and Zn levels in depression.
Objective: To determine the association between serum Zn levels, muscle strength, and depression.
Methods: An observational, analytical case-control study. 103 depressive patients hospitalized at the San Juan de Dios Clinic in Manizales, and 36 controls with no personal history of mental illness were evaluated for depression severity, serum zinc levels (Zn), and handgrip strength. The groups were matched by sex, age, educational level, and socioeconomic stratum. The severity of depression was assessed using the Montgomery–Asberg Rating Scale (MADRS). Serum Zn levels were determined, and handgrip strength was assessed using dynamometer. Descriptive analysis, logistic regression and linear models were performed with depression and severity of depression as dependent variables.
Results: Lower Zn levels and reduced handgrip strength were related to the presence of depression with the logistic model. Lower handgrip strength and severity of depression were associated with the linear model.
Conclusion: An association was found between depression and low Zn levels, and an inverse association between severity of depression and muscle strength. Future studies should investigate causality, and to evaluate the relationship between depression, muscle strength and nutritional status.
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