Relationship between cognition and certain blood biomarkers as a function of vascular risk factors.

Authors

  • Javier Sanchez-Betancourt UNAM/FCAyS-UABC
  • Jorge Alberto Guzmán Cortés
  • Maria Rosa Avila-Costa

DOI:

https://doi.org/10.12873/441sanchez

Keywords:

Biomarkers, Lifestyle, Cognition, HbA1C, Lipids

Abstract

Introduction. Alterations in cognitive function have been found in disorders such as obesity, type 2 diabetes mellitus (DMT-II). One possibility to understand the relationship between cognition and these disorders are biomarkers in blood. Objective. The objective was to determine the relationship of glycated hemoglobin (HbA1c) and lipids with the cognitive performance of patients who are exposed to several vascular risk factors compared to patients who have fewer risk factors. Methodology. Non-probabilistic convenience sampling was carried out. Adults of both sexes who were over 18 years of age and who had a risk factor such as a sedentary lifestyle and/or a diagnosis of DMT-II, hypertension or obesity were considered. Participants who did not have these risk factors and who led an active lifestyle were also considered. The participants (n=28) were evaluated using the Dspan, Mspan and MoCa neuropsychological tests and the levels of glycosylated hemoglobin (HbA1c), cholesterol (HDL and LDL) and triglycerides (TG) were determined. Results. It was found that high levels of HbA1c and TG were associated with a low score on the MoCA test, while high levels of HDL were associated with better cognitive performance on said test. When dividing the sample based on the number of vascular risk factors to which they have been exposed, it was found that the greater the presence of risk factors, the stronger the relationship between HbA1c and TG and the worse cognitive performance. Conclusion. It is concluded that the relationship between biomarkers and brain functions is strong and dependent on the number of vascular risk factors to which patients are exposed.

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Published

2024-02-13

How to Cite

Sanchez-Betancourt, J., Guzmán Cortés, J. A., & Avila-Costa, M. R. (2024). Relationship between cognition and certain blood biomarkers as a function of vascular risk factors. Nutrición Clínica Y Dietética Hospitalaria, 44(1). https://doi.org/10.12873/441sanchez

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Research articles

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