Effect of Euterpe oleracea (acai) on liver damage induced by fructose and ethanol in rats.
DOI:
https://doi.org/10.12873/451paredesKeywords:
Euterpe oleracea (acai), ethanol, fructose, liver damage, Transcription factorsAbstract
Introduction: Liver diseases have a high morbidity and
mortality rate worldwide, with fructose and ethanol consumption being the main triggers of structural and metabolic alterations in the adult population.
Objectives: To determine the effect of Euterpe oleracea
(acai) on fructose- and ethanol-induced liver damage in rats.
Materials: A purely experimental study with a control
group and post-test. The pulverized fruit of Euterpe oleracea (acai) was used and 30 male Holtzman rats were randomly assigned to 5 groups. The research groups received the following feeding scheme for 22 days: group I: pulverized balanced diet + water ad libitum, group II: balanced diet + 5% ethanol with 15% fructose, group III, IV and V: balanced diet with 1%, 3% and 9% acai, respectively + 5% ethanol with 15% fructose. After treatment, the animals
were anesthetized and subjected to partial hepatectomy,
removing a portion of the right medial lateral lobe (MLLL)
for processing histological slides and a portion of the left
medial lateral lobe (MLLL) for processing transcriptional in
dicators with the averages obtained.
Results: Euterpe oleracea (acai) ingestion increased the ex
pression levels of PPAR-α, PPAR-α /SREBP 1-c and PPAR-ɣ
/SREBP 1-c and decreased PPAR-ɣ and SREBP-1c. The histolo
gical profile showed less periportal and sinusoidal inflammation and congestion of centrilobular veins compared to controls.
Conclusions: Ingestion of Euterpe oleracea (acai) powder
had a hepatoprotective effect against the damage induced by ethanol and fructose consumption in rats.
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