Anticancer Properties of Caulerpa racemosa: A Review Study.
DOI:
https://doi.org/10.12873/423permatasariPalabras clave:
Functional food, Caulerpa racemosa, cancer, antiproliferative, cytotoxicity, apoptotic, nutraceutical, bioactiveResumen
Introduction: Cancer is the leading cause of death in the
world, with approximately 10 million deaths expected by
2020. Several approaches are used in cancer management.
However, the cost is one of the main obstacles in cancer therapy as well as side effects in sufferers. Caulerpa racemosa is a type of seaweed that is naturally abundant in the
Indonesian sea. Recently, there has been much research on
the anticancer effects of Caulerpa sp. This study aims to find
the potency of Sea grapes extract (Caulerpa racemosa) in the
treatment of cancer and its mechanisms.
Method: A review of the literature was constructed on the
potential of the C. racemosa extract with the PICOS criteria
and the data were extracted from ‘PUBMED’, ‘ScienceDirect’
and ‘SpringerLink’. The search method was using a boolean
operator with the main keywords ‘Caulerpa racemosa’, ‘cancer’, and ‘Management’.
Results: The main results were 8 articles including in vitro
and in vivo experimental studies based on inclusion criteria.
Several studies (n=8) revealed the potency of C. racemosa
extract as an anticancer agent through various activities, such
as antiproliferative, apoptotic, antioxidant, cytotoxic activity,
and inhibition of tumor progression genes, DNMT, and upregulation of proapoptotic genes, including BAX, P53, Caspase-3, Caspase-8, and Caspase-9.
Discussion: C. racemosa possesses several potent antioxidant substances, along with gene regulation activities and in hibition of cell line proliferation. Seaweeds has been used
widely as functional food and showed minimal or no toxicities
against human. With all these benefits, C. racemosa has the
potential to be commercialized as a promising diet for cancer
patients.
Conclusion: Sea grapes extract (C. racemosa) has good
potential as an anticancer agent through antiproliferation
mechanisms, induction of apoptosis, cytotoxic and antioxidant
activity.
Citas
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