Assessing the relationship between dietary pattern and Menopausal quality of life among euthyroid and hypothyroid disorder perimenopausal women.


  • Shanthini Priya Prakash SRM Medical College Hospital and Research Centre
  • Silambu Selvi Kumbamoorthy


Palabras clave:

Perimenopausal Women, Euthyroid, Hypothyroid, QoL, 24 hour dietary recall.


Background: Thyroid disorders are found to be the most common endocrine disorders among women in India. Perimenopause women during the transition through menopause experience specific symptoms such as mood swings, hot flashes, sleep disturbances, forgetfulness, weight gain and vaginal dryness. These symptoms disturb the perimenopausal women’s day-to-day life and lead to a decrease in the quality of life (QoL).

Aim: To assess the relationship between dietary pattern and QoL among euthyroid and hypothyroid perimenopausal women.

Methods: This community-based cross-sectional study comprised 96 perimenopausal women participants among them 54 had euthyroid and 42 had the hypothyroid condition. This study was conducted in a selected area of Chengalpattu district, Tamil Nadu, India between January 2022 and April 2022. A standardized Menopause Quality of Life questionnaire (MENQOL) tool was used to assess their QoL and the dietary pattern was analyzed using 24 hr recall method. Data were analyzed statistically.

 Results: The dietary pattern of the euthyroid group (18.5%) was good compared to the hypothyroid group (9.5%). The QoL of the euthyroid group (41.7%) was more normal than the hypothyroid group (14.7%). The correlation was found to be positive (R= 0.468) and the test was significant (P < 0.01).  

Conclusion: This study concluded that there is a positive relationship between the dietary pattern and QoL among perimenopausal women having thyroid dysfunction.


Sriram UJIJoE, Metabolism. Applying a Women’s Health Lens to Endocrine and Metabolic Disorders. Indian Journal of Endocrinology and Metabolism. 2021;25(3):171.’doi’: 2230-8210.328899.

Chiovato L, Magri F, Carlé AJAit. Hypothyroidism in context: where we’ve been and where we’re going. Advances in therapy. 2019; 36:47-58. ’doi’:

Unnikrishnan AG, Kalra S, Sahay RK, Bantwal G, John M, Tewari NJIjoe, et al. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian journal of endocrinology and metabolism. 2013;17(4):647.’doi’:10.4103/22308210.113755.

Bagcchi SJTld, endocrinology. Hypothyroidism in India: more to be done. The lancet diabetes & endocrinology. 2014;2(10):778. ’doi’:

Ren B, Zhu YJIJoMS. A new perspective on thyroid hormones: crosstalk with reproductive hormones in females. International Journal of Molecular Sciences. 2022;23(5):2708.’doi’: /10.3390/ijms23052708.

Cathey AL, Watkins DJ, Rosario ZY, Vega CMV, Loch-Caruso R, Alshawabkeh AN, et al. Polycyclic aromatic hydrocarbon exposure results in altered CRH, reproductive, and thyroid hormone concentrations during human pregnancy. Science of the total environment. 2020;749:141581.’doi’: totenv.2020.141581.

Gietka-Czernel MJMRPM. The thyroid gland in postmenopausal women: physiology and diseases. Menopause Review/Przegląd Menopauzalny. 2017;16(2):33-7.’doi’: pm.2017.68588.

Abdel-Dayem MM, Elgendy MSJBrn. Effects of chronic estradiol treatment on the thyroid gland structure and function of ovariectomized rats. BMC research notes. 2009;2:1-7.’doi’:


Santin AP, Furlanetto TWJJotr. Role of estrogen in thyroid function and growth regulation. Journal of thyroid research. 2011; 2011.’doi’:

Leng O, Razvi SJTr. Hypothyroidism in the older population. Thyroid research 2019;12(1):1-10.’doi’: s13044-019-0063-3.

Barbesino GJG. Thyroid function changes in the elderly and their relationship to cardiovascular health: a mini-review. Gerontology. 2019;65(1):1-8.’doi’:

Panda S, Das AJJoM-lH. Analyzing thyroid dysfunction in the climacteric. Journal of Mid-life Health. 2018;9(3):113.’doi’:

Uygur M, Yoldemir T, Yavuz DJC. Thyroid disease in the perimenopause and postmenopause period. Climacteric. 2018; 21(6):542-8.’doi’: 1514004.

Slopien R, Owecki M, Slopien A, Bala G, Meczekalski BJJoei. Climacteric symptoms are related to thyroid status in euthyroid menopausal women. Journal of endocrinological investigation. 2020;43:75-80.’doi’:

Oi N, Ohi KJC. Comparison of the symptoms of menopause and symptoms of thyroid disease in Japanese women aged 35–59 years. Climacteric. 2013;16(5):555-60.’doi’: 10.3109/13697137.2012.717995.

Hess R, Thurston RC, Hays RD, Chang C-CH, Dillon SN, Ness RB, et al. The impact of menopause on health-related quality of life: results from the STRIDE longitudinal study. Gerontology. 2012;21:535-44.’doi’:

Mishra G, Kuh DJSs, medicine. Perceived change in quality of life during the menopause. Social Science & Medicine. 2006; 62(1):93-102.’doi’: 2005.05.015.

Nayak G, Kamath A, Kumar P, Rao AJJom-lh. A study of quality of life among perimenopausal women in selected coastal areas of Karnataka, India. Journal of mid-life health. 2012;3(2):71. ’doi’:

Nappi RE, Kroll R, Siddiqui E, Stoykova B, Rea C, Gemmen E, et al. Global cross-sectional survey of women with vasomotor symptoms associated with menopause: prevalence and quality of life burden. Menopause. 2021;28(8):875.’doi’: 97/GME.0000000000001793.

Gastaldo D, Rivas-Quarneti N, Magalhães L, editors. Body-map storytelling as a health research methodology: Blurred lines creating clear pictures. Forum Qualitative Sozialforschung/Forum: Qualitative Social Research; 2018: DEU.

Mohamed H, Lamadah SM, Zamil LGAJIJoR, Contraception, Obstetrics, Gynecology. Quality of life among menopausal women. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2014;3(3):552-61.’doi’: /10.5455/2320-1770.ijrcog20140906.

Im E-O, Ham OK, Chee E, Chee WJWjonr. Physical activity and depressive symptoms in four ethnic groups of midlife women. Western journal of nursing research. 2015;37(6):746-66. ’doi’:

Davis SR, Santoro N, Lambrinoudaki I, Lumsden M, Mishra GD, Pal L, et al. Authors’ reply: communicating evidence-based practice in menopause. Nature reviews Disease primers. 2015;1(1): 15032.’doi’:

Okhai H, Dragomir L, Pool ER, Sabin CA, Miners A, Sherr L, et al. Association between health-related quality of life and menopausal status and symptoms in women living with HIV aged 45–60 years in England: An analysis of the PRIME study. Women’s Health. 2022;18:17455065211068722.’doi’: 55065211068722.

Schultz NM, Morga A, Siddiqui E, Rhoten SEJAiT. Psychometric evaluation of the MENQOL instrument in women experiencing vasomotor symptoms associated with menopause. 2024:1-20.

Martin CM, Larroy C, López-Picado A, Fernández-Arias IJM. Accuracy of the Menopause Rating Scale and the Menopause Quality of Life Questionnaire to discriminate menopausal women with anxiety and depression. Menopause. 2019;26(8):856-


Bień A, Korżyńska-Piętas M, Zarajczyk M, Wysokiński M,

Niewiadomska I, Jurek K, et al., editors. Factors Determining the Quality of Life of Polish Women during Menopause Based on the Menopause-Specific Quality of Life Questionnaire. Healthcare; 2023: MDPI.

Almon WK, Siregar MFG, Tala MRZ, Sitepu M, Adenin I, Lubis MPJOAMJoMS. Effect of Soy Isoflavones Compared to Estradiol Valerate in Menopausal Women assessed by Menopause Quality of Life Questionnaire. Open Access Macedonian Journal of Medical Sciences. 2022;10(B):752-6.’doi’: /oamjms.2022.8749.

Ibrahim Z, Ghoneim H, Madny E, Kishk E, Lotfy M, Bahaa A, et al. The effect of menopausal symptoms on the quality of life among postmenopausal Egyptian women. Climacteric. 2020;23(1):9-


Gazibara T, Kovacevic N, Nurkovic S, Kurtagic I, Radovanovic S, Rancic B, et al. Menopause-specific Quality of Life Questionnaire: factor and Rasch analytic approach. Climacteric. 2019;22(1):90-


Radtke JV, Terhorst L, Cohen SMJM. The Menopause-Specific Quality of Life (MENQOL) questionnaire: psychometric evaluation among breast cancer survivors. Menopause 2011;18(3): 289.’doi’:

Dalal PK, Agarwal MJIjop. Postmenopausal syndrome. Indian journal of psychiatry. 2015;57(Suppl 2):S222.’doi’: 10.4103/0019-5545.161483.

Herber-Gast G-CM, Mishra GDJTAoCN. Fruit, Mediterranean-style, and high-fat and-sugar diets are associated with the risk of night sweats and hot flushes in midlife: results from a prospective cohort study. The American of Clinical Nutrition. 2013;97(5):1092-9.

Di Matteo RDJN. Mediterranean diet as tool to manage obesity in menopause: A narrative review. Nutrition (Burbank, Los Angeles County, Calif). 2020;79:110991-.’doi’:


Flor-Alemany M, Marín-Jiménez N, Nestares T, Borges-Cosic M, Aranda P, Aparicio VJM. Mediterranean diet, tobacco consumption and body composition during perimenopause. The FLAMENCO project. Maturitas. 2020;137:30-6.’doi’:


Juppi H-K, Sipilä S, Cronin NJ, Karvinen S, Karppinen JE, Tammelin TH, et al. Role of menopausal transition and physical activity in loss of lean and muscle mass: a follow-up study in middle-aged Finnish women. Journal of clinical medicine. 2020; 9(5):1588.’doi’:

Silva T, Oppermann K, Reis F, Spritzer PJNiG. Nutrition in Menopausal Women: A Narrative Review. Nutrients 2021, 13, 2149. Nutrients. 2021:51.’doi’: 072149.

Kalarhoudi MA, Taebi M, Sadat Z, Saberi FJIRCMJ. Assessment of quality of life in menopausal periods: a population study in kashan, iran. Iranian Red Crescent Medical Journal. 2011;13(11):811.

Surendar R, Durgapriya G, Arthi M, Srikanth SJPHRIJOPHR. Quality of life among post-menopausal women in rural Puducherry. International Journal Of Public Health Research. 2019;6(3):112-8.

Sagdeo M, Arora DJJs. Menopausal symptoms: A comparative study in rural and urban women. Jk science. 2011;13(1):23.

Vijayalakshmi S, Chandrababu RJJoH, NU AS. Menopausal transition among northern Indian women. Journal of Health and Allied Sciences. 2013;3(02):073-9.’doi’:




Cómo citar

Prakash, S. P., & Silambu Selvi Kumbamoorthy. (2024). Assessing the relationship between dietary pattern and Menopausal quality of life among euthyroid and hypothyroid disorder perimenopausal women. Nutrición Clínica Y Dietética Hospitalaria, 44(2).