Effect of Intermittent Fasting on Improve Body Composition and Anthropometric Measurements of Women with Polycystic Ovarian Syndrome.




Palabras clave:

fasting, fat, insulin, muscle, overweight


Introduction: Polycystic ovary syndrome is a metabolic
disorder that affects women of reproductive age and is associated with insulin resistance.
Objectives: The study aims to evaluate the effect of intermittent fasting and dietary intervention in improving anthropometric measures and body composition.
Material and Methods: An interventional trial was carried
out on eighty-six women between the ages of 19 and 40 with a body mass index of more than 25 kg/m2 were assigned to two intervention groups: the first group (n = 57) followed intermittent fasting plus dietary restriction, and the second group (n = 29) followed dietary restriction without intermittent fasting.
Results: The results show that the fasting polycystic ovarian syndrome women experienced a significant (P < 0.05) increase in muscle mass (2.2 ± 2.4) compared to the non-fasting group (0.01 ± 1.5). At the end of the intervention, fasting women with the polycystic ovarian syndrome had significantly (P < 0.05) lost weight (9.2 ± 4.5kg), fat mass % (4.6 ± 3.4), and visceral fat (2.3 ± 2.1 kg), while gaining muscle mass (2.2 ± 2.4 kg). However, non-fasting women with polycystic ovarian syndrome showed significantly reduced body weight (2.4 ± 0.4 kg), fat mass % (1.2 ± 1.1), and visceral fat (0.5 ± 0.7). The results of the linear regression model showed that the highest effect of intermittent fasting was seen in weight, fat-free mass, and muscle mass. Body fat mass changed by 93% under the effect of intermittent fasting.
Conclusion: Intermittent fasting may improve health outcomes, reduce body fat, maintain muscle mass, and aid
weight loss in women with polycystic ovarian syndrome.
Large-scale randomized controlled trials can improve our understanding of intermittent fasting in polycystic ovarian syndrome.


Al-Rshoud F, Kilani R, Al-Asali F, Alsharaydeh I, Mahfouz I. The

Prevalence of uterine septum in polycystic ovarian syndrome

(PCOS), a series of 49 cases. Jordan Medical Journal 54(3):131-136

Barber TM, Hanson P, Weickert MO, Franks S. Obesity and polycystic ovary syndrome: implications for pathogenesis and novel

management strategies. Clin Med Insights Reprod Health.

;13:1179558119874042. doi: 10.1177/1179558119874042.

Calcaterra V, Verduci E, Cena H, Magenes VC, Todisco CF, Tenuta

E, Gregorio C, De Giuseppe R, Bosetti A, Di Profio E, Zuccotti G.

Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with

Obesity: The Role of Nutrition Therapy and Food Supplements as

a Strategy to Protect Fertility. Nutrients. 2021 May 28;13(6):

doi: 10.3390/nu13061848.

Siemienowicz KJ, Coukan F, Franks S, Rae MT, Duncan WC.

Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS).

Mol Cell Endocrinol. 2021 Jan 1;519:111042. doi: 10.1016/j.mce.


Shishehgar F, Ramezani Tehrani F, Mirmiran P, Hajian S,

Baghestani AR, Moslehi N. Comparison of Dietary Intake between

Polycystic Ovary Syndrome Women and Controls. Glob J Health

Sci. 2016 Sep 1;8(9):54801. doi: 10.5539/gjhs.v8n9p302.

Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. Nutritional

management in women with polycystic ovary syndrome: A review

study. Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S429-S432.

doi: 10.1016/j.dsx.2017.03.030.

Shahdadian F, Ghiasvand R, Abbasi B, Feizi A, Saneei P,

Shahshahan Z. Association between major dietary patterns and

polycystic ovary syndrome: evidence from a case-control study.

Appl Physiol Nutr Metab. 2019 Jan;44(1):52-58. doi: 10.1139/


Salleh SN, Fairus AAH, Zahary MN, Bhaskar Raj N, Mhd Jalil AM.

Unravelling the Effects of Soluble Dietary Fibre Supplementation on

Energy Intake and Perceived Satiety in Healthy Adults: Evidence

from Systematic Review and Meta-Analysis of RandomisedControlled Trials. Foods. 2019 Jan 6;8(1):15. doi: 10.3390/foods

Gołąbek KD, Regulska-Ilow B. Dietary support in insulin resistance: An overview of current scientific reports. Adv Clin Exp Med.

Nov;28(11):1577-1585. doi: 10.17219/acem/109976.

Kazemi M, Hadi A, Pierson RA, Lujan ME, Zello GA, Chilibeck PD.

Effects of Dietary Glycemic Index and Glycemic Load on

Cardiometabolic and Reproductive Profiles in Women with

Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Adv Nutr. 2021 Feb 1;12(1):

-178. doi: 10.1093/advances/nmaa092.

Bykowska-Derda A, Czlapka-Matyasik M, Kaluzna M, Ruchala M,

Ziemnicka K. Diet quality scores in relation to fatness and nutritional knowledge in women with polycystic ovary syndrome:

case-control study. Public Health Nutr. 2021 Aug;24(11):3389-

doi: 10.1017/S1368980020001755.

Gabel K, Hoddy KK, Haggerty N, Song J, Kroeger CM, Trepanowski

JF, Panda S, Varady KA. Effects of 8-hour time restricted feeding

on body weight and metabolic disease risk factors in obese adults:

A pilot study. Nutr Healthy Aging. 2018 Jun 15;4(4):345-353.

doi: 10.3233/NHA-170036.

Barnosky AR, Hoddy KK, Unterman TG, Varady KA. Intermittent

fasting vs daily calorie restriction for type 2 diabetes prevention:

a review of human findings. Transl Res. 2014 Oct;164(4):302-11.

doi: 10.1016/j.trsl.2014.05.013.

Tinsley GM, Forsse JS, Butler NK, Paoli A, Bane AA, La Bounty PM,

Morgan GB, Grandjean PW. Time-restricted feeding in young men

performing resistance training: A randomized controlled trial. Eur

J Sport Sci. 2017 Mar;17(2):200-207. doi: 10.1080/17461391.20


Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM.

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood

Pressure, and Oxidative Stress Even without Weight Loss in Men

with Prediabetes. Cell Metab. 2018 Jun 5;27(6):1212-1221.e3.

doi: 10.1016/j.cmet.2018.04.010.

Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop

group. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS).

Hum Reprod. 2004 Jan;19(1):41-7. doi: 10.1093/humrep/deh098.

Morales Camacho WJ, Molina Díaz JM, Plata Ortiz S, Plata Ortiz

JE, Morales Camacho MA, Calderón BP. Childhood obesity:

Aetiology, comorbidities, and treatment. Diabetes Metab Res Rev.

Nov;35(8):e3203. doi: 10.1002/dmrr.3203.

Xing C, Li C, He B. Insulin Sensitizers for Improving the Endocrine

and Metabolic Profile in Overweight Women With PCOS. J Clin

Endocrinol Metab. 2020 Sep 1;105(9):2950–63. doi: 10.1210/


Carreau A-M, Baillargeon J-PJCdr. PCOS in adolescence and type

diabetes. Curr Diab Rep. 2015;15(1):564. doi: 10.1007/s11892-


Legro RS, Dodson WC, Kris-Etherton PM, Kunselman AR, Stetter

CM, Williams NI, Gnatuk CL, Estes SJ, Fleming J, Allison KC,

Sarwer DB, Coutifaris C, Dokras A. Randomized Controlled Trial of

Preconception Interventions in Infertile Women With Polycystic

Ovary Syndrome. J Clin Endocrinol Metab. 2015 Nov;100(11):

-58. doi: 10.1210/jc.2015-2778.

Begum GS, Shariff A, Ayman G, Mohammad B, Housam R, Khaled

NJd. Assessment of risk factors for development of polycystic

ovarian syndrome. International Journal of Contemporary Medical

Research. 2017; 4 (1).

Zhao H, Zhang J, Cheng X, Nie X, He B. Insulin resistance in polycystic ovary syndrome across various tissues: an updated review

of pathogenesis, evaluation, and treatment. J Ovarian Res. 2023

Jan 11;16(1):9. doi: 10.1186/s13048-022-01091-0.

Che X, Chen Z, Liu M, Mo Z. Dietary Interventions: A Promising

Treatment for Polycystic Ovary Syndrome. Ann Nutr Metab. 2021;

(6):313-323. doi: 10.1159/000519302.

Conley M, Le Fevre L, Haywood C, Proietto J. Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study. Nutr Diet. 2018

Feb;75(1):65-72. doi: 10.1111/1747-0080.12372.

Harvie M, Howell A. Potential Benefits and Harms of Intermittent

Energy Restriction and Intermittent Fasting Amongst Obese,

Overweight and Normal Weight Subjects-A Narrative Review of

Human and Animal Evidence. Behav Sci (Basel). 2017 Jan

;7(1):4. doi: 10.3390/bs7010004.

Marzouk TM, Sayed Ahmed WA. Effect of Dietary Weight Loss on

Menstrual Regularity in Obese Young Adult Women with

Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2015

Dec;28(6):457-61. doi: 10.1016/j.jpag.2015.01.002.

Harris L, Hamilton S, Azevedo LB, Olajide J, De Brún C, Waller G,

Whittaker V, Sharp T, Lean M, Hankey C, Ells L. Intermittent fasting interventions for treatment of overweight and obesity in adults:

a systematic review and meta-analysis. JBI Database System Rev

Implement Rep. 2018 Feb;16(2):507-547. doi: 10.11124/JBISRIR2016-003248

De Cabo R, Mattson MP. Effects of Intermittent Fasting on Health,

Aging, and Disease. N Engl J Med. 2019 Dec 26;381(26):2541-

doi: 10.1056/NEJMra1905136..

Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG

rd, Leeuwenburgh C, Mattson MP. Flipping the Metabolic Switch:

Understanding and Applying the Health Benefits of Fasting. Obesity

(Silver Spring). 2018 Feb;26(2):254-268. doi: 10.1002/oby.22065.

Carlson O, Martin B, Stote KS, Golden E, Maudsley S, Najjar SS,

Ferrucci L, Ingram DK, Longo DL, Rumpler WV, Baer DJ, Egan J,

Mattson MP. Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middleaged men and women. Metabolism. 2007 Dec;56(12):1729-34.

doi: 10.1016/j.metabol.2007.07.018.




Cómo citar

Abu Salma, B., Thekrallah, F., Qatawneh, A., Hasan, H., Shawaqfeh, S., & Altarawneh, M. (2024). Effect of Intermittent Fasting on Improve Body Composition and Anthropometric Measurements of Women with Polycystic Ovarian Syndrome. Nutrición Clínica Y Dietética Hospitalaria, 44(2). https://doi.org/10.12873/442abu



Artículos originales