Evaluation of the blood lipid profile pattern in female breast cancer patients in Jordan.
DOI:
https://doi.org/10.12873/444alsarhanPalabras clave:
Body mass index, triglycerides, total cholesterol, and breast cancer.Resumen
Background: Breast cancer is a cancerous growth impacting approximately 2.26 million women globally, The World Health Organization reports that it is thought to be the tumor in women that is diagnosed the most commonly. development.Objective: Examining any possible correlation between serum lipid concentrations and the cancer of the breast in a community sample of Jordanian women is the primary goal of the current investigation.Methods: In this study 122 subjects were included, patient group consists of 94 women diagnosed breast cancer, where control group consists of 28 healthy women. Samples of Venous blood were collected from participant’s subjects, after centrifugation obtained serum was used for assessment of Triglycerides, total cholesterol, and HDL –cholesterol levels using fully automated analyzer for biochemistry. The Fried Wald equation was applied for calculating serum concentrations of LDL-Cholesterol Results: After comparison with control group, a strong positive significant notable elevation was observed between the BMI values of the breast cancer patients. (28.8 ± 3.9 vs. 25.2 ± 4.3 kg/m2, p >0.005). The patient group's serum levels of total cholesterol and triglycerides were observed to be considerably higher than those of the control group. (230.7 ± 86.9 vs. 177.6 ± 44.5 mg/dL, p >0.005) and (209.4 ± 95.9 vs. 175.7 ± 45.6 mg/dL, p >0.005) respectively. On other hand, the patients' group's blood LDL-cholesterol levels were found to be higher (122.8 ± 25.5 vs. 115.9 ± 26.9mg/dL, p >0.005). There was no notable alteration in Serum HDL-Cholesterol levels among the two group.Conclusion: The current study's results indicate a clear correlation between increased body mass index (BMI), altered lipid profiles, and an increasing of risk of breast cancer in women living in Jordan.
Citas
Momenimovahed Z, Salehiniya H (2019) Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer: Targets and Therapy 151–164
Arnold M, Morgan E, Rumgay H, et al (2022) Current and future burden of breast cancer: Global statistics for 2020 and 2040. The Breast 66:15–23.
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, Published online 4 April 2024;
Hikmat A ,Asem M. Challenges and Opportunities in Breast Cancer Care in Low-Resourced Countries, Jordan as An Example Cancers 2024, 16(9), 1751;
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021; 71(1):7–33.
Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis. 2018;5(2):77–106
Xing L, Jing L, Tian Y, et al. Epidemiology of dyslipidemia and associated cardiovascular risk factors in northeast China: a cross-sectional study. Nutr Metab Cardiovasc Dis 2020; 30: 2262–2270.
Jung SM, Kang D, Guallar E, et al. Impact of serum lipid on breast cancer recurrence. J Clin Med 2020; 9: 2846.
Lofterød T, Mortensen ES, Nalwoga H, et al. Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes. BMC Cancer 2018; 18: 654.
Buono G, Crispo A, Giuliano M, et al. Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study. Breast Cancer Res Treat 2020; 182: 401–409.
Li X., Liu Z.-L., Wu Y.-T., Wu H., Dai W., Arshad B., Xu Z., Li H., Wu K.-N., Kong L.-Q. Status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. Lipids Health Dis. 2018; 17:91. doi: 10.1186/s12944-018-0745-
Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000; 894: i-xii, 1-253.
WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004 Jan 10; 363(9403):157-63.
Harborg S, Ahern TP, Feldt M, et al. Circulating lipids and breast cancer prognosis in the Malmö diet and cancer study. Breast Cancer Res Treat 2022; 191: 611–621.
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209–249..
Tojikhujaeva S (2022) Breast Cancer and Their Treatment. Central Asian Journal of Medical and Natural Science 3: https://doi.org/10.17605/OSF.IO/ESWQA.
Kumar V, Singh A, Sidhu DS, Panag K (2015) A comparitive study to evaluate the role of serum lipid levels in aetiology of carcinoma breast. J Clin Diagn Res 9:PC01
Chan DSM, Vieira AR, Aune D, et al (2014) Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies. Annals of Oncology 25:1901–1914.
Raza U, Asif MR, Rehman A Bin, Sheikh A (2018) Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage. Pak J Med Sci 34:209
Touvier M, Fassier P, His M, et al (2015) Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies. British Journal of Nutrition 114:347–357.
Engin A (2017) Obesity-associated breast cancer: analysis of risk factors. Obesity and lipotoxicity 571–606.
Ajlouni K, Khader Y, Batieha A, et al (2020) An alarmingly high and increasing prevalence of obesity in Jordan. Epidemiol Health 42:
Momenimovahed Z, Salehiniya H (2019) Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer: Targets and Therapy 151–164
Arnold M, Morgan E, Rumgay H, et al (2022) Current and future burden of breast cancer: Global statistics for 2020 and 2040. The Breast 66:15–23
Bray F, Ferlay J, Soerjomataram I, et al (2018) GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca Cancer J Clin 68:394–424
Ferlay J, Ervik M, Lam F, Colombet M (2021) Global cancer observatory. Cancer today. 2020
Yoo KY, Kang D, Park SK, et al (2002) Epidemiology of breast cancer in Korea: occurrence, high-risk groups, and prevention. J Korean Med Sci 17:1–6
Sousa-e-Silva ÉP de, Conde DM, Costa-Paiva L, et al (2014) Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models. Revista Brasileira de Ginecologia e Obstetrícia 36:157–162
Siemianowicz K, Gminski J, Stajszczyk M, et al (2000) Serum total cholesterol and triglycerides levels in patients with lung cancer. Int J Mol Med 5:201–206
Alloubani A, Nimer R, Samara R (2021) Relationship between hyperlipidemia, cardiovascular disease and stroke: a systematic review. Curr Cardiol Rev 17:52–66
Liu L, Liu Y, Zhang X, et al (2022) Dyslipidemia is associated with worse asthma clinical outcomes: a prospective cohort study. J Allergy Clin Immunol Pract. https://doi.org/https://doi.org/10.1016/j.jaip.2022.11.037
Owiredu WK, Donkor S, Addai BW, Amidu N (2009) Serum lipid profile of breast cancer patients. Pak J Biol Sci 12:332–338
Pedersen KM, Çolak Y, Bojesen SE, Nordestgaard BG (2020) Low high-density lipoprotein and increased risk of several cancers: 2 population-based cohort studies including 116,728 individuals. J Hematol Oncol 13:1–11
Samadi S, Ghayour‐Mobarhan M, Mohammadpour A, et al (2019) High‐density lipoprotein functionality and breast cancer: A potential therapeutic target. J Cell Biochem 120:5756–5765
Al-Swelmien A (2014) Serum lipid profile in breast cancer patients. Rawal medical journal 39:254–256
Al-Fawaeir S, Al-Odat I (2022) Influence of metformin intake on serum vitamin B12 levels in patients with type 2 diabetes mellitus. PLoS One 17:e0279740
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502
Tojikhujaeva S (2022) Breast Cancer and Their Treatment. Central Asian Journal of Medical and Natural Science 3:. https://doi.org/10.17605/OSF.IO/ESWQA
Kumar V, Singh A, Sidhu DS, Panag K (2015) A comparitive study to evaluate the role of serum lipid levels in aetiology of carcinoma breast. J Clin Diagn Res 9:PC01
Chan DSM, Vieira AR, Aune D, et al (2014) Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies. Annals of Oncology 25:1901–1914
Raza U, Asif MR, Rehman A Bin, Sheikh A (2018) Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage. Pak J Med Sci 34:209
Touvier M, Fassier P, His M, et al (2015) Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies. British Journal of Nutrition 114:347–357
Engin A (2017) Obesity-associated breast cancer: analysis of risk factors. Obesity and lipotoxicity 571–606
Ajlouni K, Khader Y, Batieha A, et al (2020) An alarmingly high and increasing prevalence of obesity in Jordan. Epidemiol Health 42:
Bustami M, Matalka KZ, Mallah E, et al (2021) The prevalence of overweight and obesity among women in Jordan: a risk factor for developing chronic diseases. J Multidiscip Healthc 1533–1541
Corn KC, Windham MA, Rafat M (2020) Lipids in the tumor microenvironment: From cancer progression to treatment. Prog Lipid Res 80:101055
Balaban S, Shearer RF, Lee LS, et al (2017) Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab 5:1–14
Tiwari P, Blank A, Cui C, et al (2019) Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. Journal of Experimental Medicine 216:1345–1358
Fujisaki K, Fujimoto H, Sangai T, et al (2015) Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1. Breast Cancer Res Treat 150:255–263
Tournberg SA, Holm LE, Carstensen JM (1988) Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure. Acta Oncol (Madr) 27:31–37
Abd AA (2019) Assessment of lipid profile parameters in women with benign and malignant breast tumor. Muthanna Medical Journal 6 (1):13-25
Kachhawa P, Kachhawa K, Agrawal D, et al (2018) Association of dyslipidemia, increased insulin resistance, and serum CA 15-3 with increased risk of breast cancer in urban areas of North and Central India. J Midlife Health 9:85
Akalanka HMK, Ekanayake S, Samarasinghe K (2018) Could anthropometric and lipid parameters reflect susceptibility to breast Cancer? Comparison of newly diagnosed breast Cancer and apparently healthy women. Asian Pac J Cancer Prev 19:2475
Qadir MI, Malik SA (2008) Plasma lipid profile in gynecologic cancers. Eur J Gynaecol Oncol 29:158–161
Bani IA, Williams CM, Boulter PS, Dickerson JW (1986) Plasma lipids and prolactin in patients with breast cancer. Br J Cancer 54:439–446
Laamiri FZ, Otmani A, Ahid S, Barkat A (2013) Lipid profile among Moroccan overweight women and breast cancer: a case-control study. Int J Gen Med 439–445
Bensinger SJ, Bradley MN, Joseph SB, et al (2008) LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134:97–111
Yangoua HCM, Azantsa BGK, Kuate D, et al (2019) Characterization of dyslipidemia and assessment of atherogenic risk amongst Cameroonian living in yaounde: a Cross Sectional Study. J Biosci Med (Irvine) 7:35–50
Ballard‐Barbash R (1994) Anthropometry and breast cancer. Body size‐a moving target. Cancer 74:1090–1100
Ni H, Liu H, Gao R (2015) Serum lipids and breast cancer risk: a meta-analysis of prospective cohort studies. PLoS One 10:e0142669
Goodwin PJ, Boyd NF, Hanna W, et al (1997) Elevated levels of plasma triglycerides are associated with histologically defined premenopausal breast cancer risk. Nutrition and Cancer 27:284–292
Shah FD, Shukla SN, Shah PM, et al (2008) Significance of alterations in plasma lipid profile levels in breast cancer. Integr Cancer Ther 7:33–41
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