Evaluation of the blood lipid profile pattern in female breast cancer patients in Jordan.

Ali Alsarhan; Ali Ata Alsarhan; Ibrahim Al Odat; Alia Khwaldeh; Baker Al Shara

doi:10.12873/444alsarhan

Autores/as

Ali Alsarhan Department of Allied Medical Sciences, Zarqa University College, Al-Balqa Applied University, A salt, Jordan
Ali Ata Alsarhan
Ibrahim Al Odat
Alia Khwaldeh
Baker Al Shara

DOI:

https://doi.org/10.12873/444alsarhan

Palabras clave:

Body mass index, triglycerides, total cholesterol, and breast cancer.

Resumen

Background: Breast cancer is a cancerous growth impacting approximately 2.26 million women globally, The World Health Organization reports that it is thought to be the tumor in women that is diagnosed the most commonly. development.Objective: Examining any possible correlation between serum lipid concentrations and the cancer of the breast in a community sample of Jordanian women is the primary goal of the current investigation.Methods: In this study 122 subjects were included, patient group consists of 94 women diagnosed breast cancer, where control group consists of 28 healthy women. Samples of Venous blood were collected from participant’s subjects, after centrifugation obtained serum was used for assessment of Triglycerides, total cholesterol, and HDL –cholesterol levels using fully automated analyzer for biochemistry. The Fried Wald equation was applied for calculating serum concentrations of LDL-Cholesterol Results: After comparison with control group, a strong positive significant notable elevation was observed between the BMI values of the breast cancer patients. (28.8 ± 3.9 vs. 25.2 ± 4.3 kg/m2, p >0.005). The patient group's serum levels of total cholesterol and triglycerides were observed to be considerably higher than those of the control group. (230.7 ± 86.9 vs. 177.6 ± 44.5 mg/dL, p >0.005) and (209.4 ± 95.9 vs. 175.7 ± 45.6 mg/dL, p >0.005) respectively. On other hand, the patients' group's blood LDL-cholesterol levels were found to be higher (122.8 ± 25.5 vs. 115.9 ± 26.9mg/dL, p >0.005). There was no notable alteration in Serum HDL-Cholesterol levels among the two group.Conclusion: The current study's results indicate a clear correlation between increased body mass index (BMI), altered lipid profiles, and an increasing of risk of breast cancer in women living in Jordan.

Referencias

Momenimovahed Z, Salehiniya H (2019) Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer: Targets and Therapy 151–164

Arnold M, Morgan E, Rumgay H, et al (2022) Current and future burden of breast cancer: Global statistics for 2020 and 2040. The Breast 66:15–23.

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, Published online 4 April 2024; DOI: https://doi.org/10.3322/caac.21834

Hikmat A ,Asem M. Challenges and Opportunities in Breast Cancer Care in Low-Resourced Countries, Jordan as An Example Cancers 2024, 16(9), 1751; DOI: https://doi.org/10.3390/cancers16091751

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021; 71(1):7–33. DOI: https://doi.org/10.3322/caac.21654

Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis. 2018;5(2):77–106 DOI: https://doi.org/10.1016/j.gendis.2018.05.001

Xing L, Jing L, Tian Y, et al. Epidemiology of dyslipidemia and associated cardiovascular risk factors in northeast China: a cross-sectional study. Nutr Metab Cardiovasc Dis 2020; 30: 2262–2270. DOI: https://doi.org/10.1016/j.numecd.2020.07.032

Jung SM, Kang D, Guallar E, et al. Impact of serum lipid on breast cancer recurrence. J Clin Med 2020; 9: 2846. DOI: https://doi.org/10.3390/jcm9092846

Lofterød T, Mortensen ES, Nalwoga H, et al. Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes. BMC Cancer 2018; 18: 654. DOI: https://doi.org/10.1186/s12885-018-4568-2

Buono G, Crispo A, Giuliano M, et al. Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study. Breast Cancer Res Treat 2020; 182: 401–409. DOI: https://doi.org/10.1007/s10549-020-05701-7

Li X., Liu Z.-L., Wu Y.-T., Wu H., Dai W., Arshad B., Xu Z., Li H., Wu K.-N., Kong L.-Q. Status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. Lipids Health Dis. 2018; 17:91. doi: 10.1186/s12944-018-0745- DOI: https://doi.org/10.1186/s12944-018-0745-1

Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000; 894: i-xii, 1-253.

WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004 Jan 10; 363(9403):157-63. DOI: https://doi.org/10.1016/S0140-6736(03)15268-3

Harborg S, Ahern TP, Feldt M, et al. Circulating lipids and breast cancer prognosis in the Malmö diet and cancer study. Breast Cancer Res Treat 2022; 191: 611–621. DOI: https://doi.org/10.1007/s10549-021-06462-7

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209–249.. DOI: https://doi.org/10.3322/caac.21660

Tojikhujaeva S (2022) Breast Cancer and Their Treatment. Central Asian Journal of Medical and Natural Science 3: https://doi.org/10.17605/OSF.IO/ESWQA.

Kumar V, Singh A, Sidhu DS, Panag K (2015) A comparitive study to evaluate the role of serum lipid levels in aetiology of carcinoma breast. J Clin Diagn Res 9:PC01

Chan DSM, Vieira AR, Aune D, et al (2014) Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies. Annals of Oncology 25:1901–1914.

Raza U, Asif MR, Rehman A Bin, Sheikh A (2018) Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage. Pak J Med Sci 34:209

Touvier M, Fassier P, His M, et al (2015) Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies. British Journal of Nutrition 114:347–357.

Engin A (2017) Obesity-associated breast cancer: analysis of risk factors. Obesity and lipotoxicity 571–606.

Ajlouni K, Khader Y, Batieha A, et al (2020) An alarmingly high and increasing prevalence of obesity in Jordan. Epidemiol Health 42:

Momenimovahed Z, Salehiniya H (2019) Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer: Targets and Therapy 151–164 DOI: https://doi.org/10.2147/BCTT.S176070

Arnold M, Morgan E, Rumgay H, et al (2022) Current and future burden of breast cancer: Global statistics for 2020 and 2040. The Breast 66:15–23 DOI: https://doi.org/10.1016/j.breast.2022.08.010

Bray F, Ferlay J, Soerjomataram I, et al (2018) GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca Cancer J Clin 68:394–424 DOI: https://doi.org/10.3322/caac.21492

Ferlay J, Ervik M, Lam F, Colombet M (2021) Global cancer observatory. Cancer today. 2020

Yoo KY, Kang D, Park SK, et al (2002) Epidemiology of breast cancer in Korea: occurrence, high-risk groups, and prevention. J Korean Med Sci 17:1–6 DOI: https://doi.org/10.3346/jkms.2002.17.1.1

Sousa-e-Silva ÉP de, Conde DM, Costa-Paiva L, et al (2014) Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models. Revista Brasileira de Ginecologia e Obstetrícia 36:157–162 DOI: https://doi.org/10.1590/S0100-720320140050.0002

Siemianowicz K, Gminski J, Stajszczyk M, et al (2000) Serum total cholesterol and triglycerides levels in patients with lung cancer. Int J Mol Med 5:201–206 DOI: https://doi.org/10.3892/ijmm.5.2.201

Alloubani A, Nimer R, Samara R (2021) Relationship between hyperlipidemia, cardiovascular disease and stroke: a systematic review. Curr Cardiol Rev 17:52–66 DOI: https://doi.org/10.2174/1573403X16999201210200342

Liu L, Liu Y, Zhang X, et al (2022) Dyslipidemia is associated with worse asthma clinical outcomes: a prospective cohort study. J Allergy Clin Immunol Pract. https://doi.org/https://doi.org/10.1016/j.jaip.2022.11.037 DOI: https://doi.org/10.1016/j.jaip.2022.11.037

Owiredu WK, Donkor S, Addai BW, Amidu N (2009) Serum lipid profile of breast cancer patients. Pak J Biol Sci 12:332–338 DOI: https://doi.org/10.3923/pjbs.2009.332.338

Pedersen KM, Çolak Y, Bojesen SE, Nordestgaard BG (2020) Low high-density lipoprotein and increased risk of several cancers: 2 population-based cohort studies including 116,728 individuals. J Hematol Oncol 13:1–11 DOI: https://doi.org/10.1186/s13045-020-00963-6

Samadi S, Ghayour‐Mobarhan M, Mohammadpour A, et al (2019) High‐density lipoprotein functionality and breast cancer: A potential therapeutic target. J Cell Biochem 120:5756–5765 DOI: https://doi.org/10.1002/jcb.27862

Al-Swelmien A (2014) Serum lipid profile in breast cancer patients. Rawal medical journal 39:254–256

Al-Fawaeir S, Al-Odat I (2022) Influence of metformin intake on serum vitamin B12 levels in patients with type 2 diabetes mellitus. PLoS One 17:e0279740 DOI: https://doi.org/10.1371/journal.pone.0279740

Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502 DOI: https://doi.org/10.1093/clinchem/18.6.499

Tojikhujaeva S (2022) Breast Cancer and Their Treatment. Central Asian Journal of Medical and Natural Science 3:. https://doi.org/10.17605/OSF.IO/ESWQA

Kumar V, Singh A, Sidhu DS, Panag K (2015) A comparitive study to evaluate the role of serum lipid levels in aetiology of carcinoma breast. J Clin Diagn Res 9:PC01 DOI: https://doi.org/10.7860/JCDR/2015/12273.5563

Chan DSM, Vieira AR, Aune D, et al (2014) Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies. Annals of Oncology 25:1901–1914 DOI: https://doi.org/10.1093/annonc/mdu042

Raza U, Asif MR, Rehman A Bin, Sheikh A (2018) Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage. Pak J Med Sci 34:209 DOI: https://doi.org/10.12669/pjms.341.14841

Touvier M, Fassier P, His M, et al (2015) Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies. British Journal of Nutrition 114:347–357 DOI: https://doi.org/10.1017/S000711451500183X

Engin A (2017) Obesity-associated breast cancer: analysis of risk factors. Obesity and lipotoxicity 571–606 DOI: https://doi.org/10.1007/978-3-319-48382-5_25

Ajlouni K, Khader Y, Batieha A, et al (2020) An alarmingly high and increasing prevalence of obesity in Jordan. Epidemiol Health 42: DOI: https://doi.org/10.4178/epih.e2020040

Bustami M, Matalka KZ, Mallah E, et al (2021) The prevalence of overweight and obesity among women in Jordan: a risk factor for developing chronic diseases. J Multidiscip Healthc 1533–1541 DOI: https://doi.org/10.2147/JMDH.S313172

Corn KC, Windham MA, Rafat M (2020) Lipids in the tumor microenvironment: From cancer progression to treatment. Prog Lipid Res 80:101055 DOI: https://doi.org/10.1016/j.plipres.2020.101055

Balaban S, Shearer RF, Lee LS, et al (2017) Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab 5:1–14 DOI: https://doi.org/10.1186/s40170-016-0163-7

Tiwari P, Blank A, Cui C, et al (2019) Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. Journal of Experimental Medicine 216:1345–1358 DOI: https://doi.org/10.1084/jem.20181616

Fujisaki K, Fujimoto H, Sangai T, et al (2015) Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1. Breast Cancer Res Treat 150:255–263 DOI: https://doi.org/10.1007/s10549-015-3318-2

Tournberg SA, Holm LE, Carstensen JM (1988) Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure. Acta Oncol (Madr) 27:31–37 DOI: https://doi.org/10.3109/02841868809090315

Abd AA (2019) Assessment of lipid profile parameters in women with benign and malignant breast tumor. Muthanna Medical Journal 6 (1):13-25

Kachhawa P, Kachhawa K, Agrawal D, et al (2018) Association of dyslipidemia, increased insulin resistance, and serum CA 15-3 with increased risk of breast cancer in urban areas of North and Central India. J Midlife Health 9:85 DOI: https://doi.org/10.4103/jmh.JMH_77_17

Akalanka HMK, Ekanayake S, Samarasinghe K (2018) Could anthropometric and lipid parameters reflect susceptibility to breast Cancer? Comparison of newly diagnosed breast Cancer and apparently healthy women. Asian Pac J Cancer Prev 19:2475

Qadir MI, Malik SA (2008) Plasma lipid profile in gynecologic cancers. Eur J Gynaecol Oncol 29:158–161

Bani IA, Williams CM, Boulter PS, Dickerson JW (1986) Plasma lipids and prolactin in patients with breast cancer. Br J Cancer 54:439–446 DOI: https://doi.org/10.1038/bjc.1986.195

Laamiri FZ, Otmani A, Ahid S, Barkat A (2013) Lipid profile among Moroccan overweight women and breast cancer: a case-control study. Int J Gen Med 439–445 DOI: https://doi.org/10.2147/IJGM.S40826

Bensinger SJ, Bradley MN, Joseph SB, et al (2008) LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134:97–111 DOI: https://doi.org/10.1016/j.cell.2008.04.052

Yangoua HCM, Azantsa BGK, Kuate D, et al (2019) Characterization of dyslipidemia and assessment of atherogenic risk amongst Cameroonian living in yaounde: a Cross Sectional Study. J Biosci Med (Irvine) 7:35–50 DOI: https://doi.org/10.4236/jbm.2019.77004

Ballard‐Barbash R (1994) Anthropometry and breast cancer. Body size‐a moving target. Cancer 74:1090–1100 DOI: https://doi.org/10.1002/1097-0142(19940801)74:3+<1090::AID-CNCR2820741518>3.0.CO;2-X

Ni H, Liu H, Gao R (2015) Serum lipids and breast cancer risk: a meta-analysis of prospective cohort studies. PLoS One 10:e0142669 DOI: https://doi.org/10.1371/journal.pone.0142669

Goodwin PJ, Boyd NF, Hanna W, et al (1997) Elevated levels of plasma triglycerides are associated with histologically defined premenopausal breast cancer risk. Nutrition and Cancer 27:284–292 DOI: https://doi.org/10.1080/01635589709514539

Shah FD, Shukla SN, Shah PM, et al (2008) Significance of alterations in plasma lipid profile levels in breast cancer. Integr Cancer Ther 7:33–41 DOI: https://doi.org/10.1177/1534735407313883