Anticancer Properties of Caulerpa racemosa: A Review Study.


  • Happy Kurnia PERMATASARI Biochemistry and Biomolecular, Faculty of Medicine, Brawijaya University, Malang, 65145, Indonesia.
  • Stanley BULAIN
  • Nasim AMAR
  • Maghfira Rahma AZIZAH
  • Farida Zharfani MUSLIM
  • Vanessa Pradna Adyana DAUD
  • Fahrul NURKOLIS


Palabras clave:

Functional food, Caulerpa racemosa, cancer, antiproliferative, cytotoxicity, apoptotic, nutraceutical, bioactive


Introduction: Cancer is the leading cause of death in the
world, with approximately 10 million deaths expected by
2020. Several approaches are used in cancer management.
However, the cost is one of the main obstacles in cancer therapy as well as side effects in sufferers. Caulerpa racemosa is a type of seaweed that is naturally abundant in the
Indonesian sea. Recently, there has been much research on
the anticancer effects of Caulerpa sp. This study aims to find
the potency of Sea grapes extract (Caulerpa racemosa) in the
treatment of cancer and its mechanisms.
Method: A review of the literature was constructed on the
potential of the C. racemosa extract with the PICOS criteria
and the data were extracted from ‘PUBMED’, ‘ScienceDirect’
and ‘SpringerLink’. The search method was using a boolean
operator with the main keywords ‘Caulerpa racemosa’, ‘cancer’, and ‘Management’.
Results: The main results were 8 articles including in vitro
and in vivo experimental studies based on inclusion criteria.
Several studies (n=8) revealed the potency of C. racemosa
extract as an anticancer agent through various activities, such
as antiproliferative, apoptotic, antioxidant, cytotoxic activity,
and inhibition of tumor progression genes, DNMT, and upregulation of proapoptotic genes, including BAX, P53, Caspase-3, Caspase-8, and Caspase-9.
Discussion: C. racemosa possesses several potent antioxidant substances, along with gene regulation activities and in hibition of cell line proliferation. Seaweeds has been used
widely as functional food and showed minimal or no toxicities
against human. With all these benefits, C. racemosa has the
potential to be commercialized as a promising diet for cancer
Conclusion: Sea grapes extract (C. racemosa) has good
potential as an anticancer agent through antiproliferation
mechanisms, induction of apoptosis, cytotoxic and antioxidant



Barbier, P. et al. (2001) ‘Caulerpenyne from Caulerpa taxifolia has an antiproliferative activity on tumor cell line SK-N-SH and modifies the microtubule network’, Life Sciences, 70(4), pp. 415–429. doi: 10.1016/S0024-3205(01)01396-0.

Cavas, L. et al. (2006) ‘Antiproliferative and newly attributed apoptotic activities from an invasive marine alga: Caulerpa racemosa var. cylindracea’, Journal of Experimental Marine Biology and Ecology, 339(1), pp. 111–119. doi: 10.1016/j.jembe.2006.07.019.

Chia, Y. Y. et al. (2015) ‘Antioxidant and cytotoxic activities of three species of tropical seaweeds’, BMC Complementary and Alternative Medicine, 15(1). doi: 10.1186/s12906-015-0867-1.

Cullen, J. M. and Breen, M. (2016) ‘An Overview of Molecular Cancer Pathogenesis, Prognosis, and Diagnosis’, Tumors in Domestic Animals, pp. 1–26. doi: 10.1002/9781119181200.ch1.

Forster, J. and Radulovich, R. (2015) ‘Chapter 11 – Seaweed and food security’, Seaweed Sustainability, pp. 289–313.

Gal, K. Le et al. (2015) ‘Antioxidants can increase melanoma metastasis in mice’, Science Translational Medicine, 7(308), pp. 1–8. doi: 10.1126/scitranslmed.aad3740.

Jean Mulcahy Levy, Christina G. Towers, A. T. (2017) ‘Targeting autophagy in cancer’, Cancer, 17(9), pp. 528–524. doi: 10.1002/cncr.31335.

Jung, V. et al. (2002) ‘Comparison of the wound-activated transformation of caulerpenyne by invasive and noninvasive Caulerpa species of the Mediterranean’, Journal of Chemical Ecology, 28(10), pp. 2091–2105. doi: 10.1023/A:1020710230532.

Konrath, E. L. et al. (2012) ‘Investigation of the in vitro and ex vivo acetylcholinesterase and antioxidant activities of traditionally used Lycopodium species from South America on alkaloid extracts’, Journal of ethnopharmacology, 139(1), pp. 58–67. doi: 10.1016/J.JEP.2011.10.042.

Krishnakumar, G. et al. (2012) ‘Estimation of camptothecin and pharmacological evaluation of Ophiorrhiza prostrata D. Don and Ophiorrhiza mungos L.’, Asian Pacific Journal of Tropical Biomedicine, 2(2), pp. S727–S731. doi: 10.1016/S2221-1691(12)60304-9.

Kumar, A. et al. (2018) ‘Influence of sea grapes (Caulerpa racemosa) supplementation on physical, functional, and anti-oxidant properties of semi-sweet biscuits’, Journal of Applied Phycology, 30(2), pp. 1393–1403. doi: 10.1007/s10811-017-1310-4.

Kung, H. C. et al. (2021) ‘Separation and purification of caulerpin from algal Caulerpa racemosa by simulated moving bed chromatography’, Food and Bioproducts Processing, 130, pp. 14–22. doi: 10.1016/j.fbp.2021.09.002.

Kurt, O. et al. (2009) ‘Neurotoxic effect of Caulerpa racemosa var. cylindracea by neurite inhibition on the neuroblastoma cell line’, Russian Journal of Marine Biology, 35(4), pp. 342–350. doi: 10.1134/S1063074009040105.

Lawenda, B. D. et al. (2008) ‘Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?’, Journal of the National Cancer Institute, 100(11), pp. 773–783. doi: 10.1093/JNCI/DJN148.

Liu, Y. et al. (2009) ‘The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration’, Journal of natural products, 72(12), pp. 2104–2109. doi: 10.1021/NP9005794.

Manikandakrishnan, M. et al. (2019) ‘Facile green route synthesis of gold nanoparticles using Caulerpa racemosa for biomedical applications’, Journal of Drug Delivery Science and Technology, 54(October), p. 101345. doi: 10.1016/j.jddst.2019.101345.

Mehra, R. et al. (2019) ‘Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling’, Molecular Biology Reports 2019 46:3, 46(3), pp. 3545–3555. doi: 10.1007/S11033-019-04743-5.

National Cancer Institute (2017) Antioxidants and Cancer Prevention - National Cancer Institute. Available at: (Accessed: 10 January 2022).

National Cancer Institute (2021) ‘Biomarker Testing for Cancer Treatment’, pp. 1–5. Available at:

Permatasari, H. K. et al. (2021) ‘Kombucha tea from seagrapes (Caulerpa racemosa) potential as a functional anti-ageing food: in vitro and in vivo study’, Heliyon, 7(9), p. e07944. doi: 10.1016/j.heliyon.2021.e07944.

Piskounova, E. et al. (2015) ‘Oxidative stress inhibits distant metastasis by human melanoma cells’, Nature, 527(7577), pp. 186–191. doi: 10.1038/NATURE15726.

Rahimi, H. R., Arastoo, M. and Ostad, S. N. (2012) ‘A Comprehensive Review of Punicagranatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches’, Iranian Journal of Pharmaceutical Research : IJPR, 11(2), p. 385. doi: 10.22037/ijpr.2012.1148.

Ribeiro, N. A. et al. (2014) ‘Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO-1 pathway activation’, Inflammation Research, 63(7), pp. 569–580. doi: 10.1007/s00011-014-0728-2.

Ridhowati, S. and Asnani (2016) ‘Potensi Anggur Laut Kelompok Caulerpa racemosa sebagai Kandidat Sumber Pangan Fungsional Indonesia’, XLI(4), pp. 50–62. Available at: (Accessed: 22 September 2021).

Riley, L. (WHO), Cowan, M. and Alwan, A. (2010) ‘Assessing National Capacity for the Prevention and Control of Noncommunicable diseases. Report of the 2010 Global Survey’, (March), p. 82. Available at:

Sayin, V. I. et al. (2014) ‘Antioxidants accelerate lung cancer progression in mice’, Science translational medicine, 6(221). doi: 10.1126/SCITRANSLMED.3007653.

Singh, N. et al. (2019) ‘Inflammation and cancer’, Annals of African medicine, 18(3), pp. 121–126. doi: 10.4103/AAM.AAM_56_18.

Tanna, B., Choudhary, B. and Mishra, A. (2018) ‘Metabolite profiling, antioxidant, scavenging and anti-proliferative activities of selected tropical green seaweeds reveal the nutraceutical potential of Caulerpa spp.’, Algal Research, 36(July), pp. 96–105. doi: 10.1016/j.algal.2018.10.019.

Tanna, B., Yadav, S. and Avinash, M. (2020) ‘Anti-proliferative and ROS-inhibitory activities reveal the anticancer potential of Caulerpa species’, Molecular biology reports, 47(10), pp. 7403–7411. doi: 10.1007/S11033-020-05795-8.

Wangchuk, P. (2018) ‘Therapeutic Applications of Natural Products in Herbal Medicines, Biodiscovery Programs, and Biomedicine’,, 8(1), pp. 1–20. doi: 10.1080/22311866.2018.1426495.

WHO (2021) Cancer. Available at: (Accessed: 5 January 2022).

Xiao, X. et al. (2018) ‘Novel racemosin B derivatives as new therapeutic agents for aggressive breast cancer’, Bioorganic and Medicinal Chemistry, 26(23–24), pp. 6096–6104. doi: 10.1016/j.bmc.2018.11.014.

Yang, P. et al. (2015) ‘Bioactive constituents from the green alga Caulerpa racemosa’, Bioorganic and Medicinal Chemistry, 23(1), pp. 38–45. doi: 10.1016/j.bmc.2014.11.031.

Yap, W. F. et al. (2019) ‘Decoding Antioxidant and Antibacterial Potentials of Malaysian Green Seaweeds: Caulerpa racemosa and Caulerpa lentillifera’, Antibiotics, 8(3). doi: 10.3390/ANTIBIOTICS8030152.

Yi, Y. et al. (2019) ‘Role of p53 family proteins in metformin anti-cancer activities’, Journal of Cancer, 10(11), pp. 2434–2442. doi: 10.7150/jca.30659.

Zhang, W. and Xu, J. (2017) ‘DNA methyltransferases and their roles in tumorigenesis’, Biomarker Research, 5(1), pp. 1–8. doi: 10.1186/s40364-017-0081-z.




Cómo citar

PERMATASARI, H. K., BULAIN, S., AMAR, N., AZIZAH, M. R., MUSLIM, F. Z., DAUD, V. P. A., & NURKOLIS, F. (2022). Anticancer Properties of Caulerpa racemosa: A Review Study. Nutrición Clínica Y Dietética Hospitalaria, 42(3).