A systematic review of oncologic pathways in cervical cancer and the correlation with dietary factors: insights into molecular mechanisms and nutritional influences.
DOI:
https://doi.org/10.12873/444deboraPalabras clave:
cervical cancer, oncologycal pathway, dietary factorResumen
Introduction: Cancer is currently the second greatest cause of death worldwide. Cervical cancer, the second most common malignancy in women worldwide, is characterized by dysregulated oncologic pathways contributing to its progression.
Goals : This systematic review aims to explore the role of different oncologic pathways in cervical cancer progression and the impact of diet on these pathways.
Methods: A systematic literature review was conducted using the PRISMA system and flow charts for quality assurance. The PICOS framework was used for inclusion criteria. Keywords used in six databases included ("signaling pathway") AND ("pathology") AND ("oncogenic") AND ("cervical cancer"). A risk of bias assessment was conducted on selected studies using the QUIN tool for in vitro studies.
Results: Nineteen studies were analyzed. Desired outcomes included induced proliferation, inhibited apoptosis, invasion-metastasis promotion, and angiogenesis. Identified oncologic pathways based on these outcomes include P53, TNF-mediated, FOXM1/WNT/β-catenin, EGFR, VEGF, NF-κB, Her-2, Histone 3, ERCC1, JAK/STAT, TGF-β, ErbB, BMP4/Hippo/ YAP1/TAZ, and ERK/c-Myc pathways. Nutritional factors, such as a western diet with processed meats, salty foods, chips, red meat, and instant foods, were found to affect the hyperactivation of these oncologic pathways, increasing cervical cancer risk.
Discussion: Each oncologic pathway has distinct mechanisms but some share similarities in triggering tumorigenesis. Increased proliferation results from heightened cell cycle activity and reduced tumor suppressor gene function. The suppression of caspase activity and pro-apoptotic proteins causes apoptosis inhibition. Metastasis and angiogenesis are driven by elevated expression of EMT and MMP proteins, promoting cancer cell invasion, migration, and new blood vessel formation. Nutritional factors influence these pathways, emphasizing the role of diet in cervical cancer progression and prevention.
Conclusion: Various and interconnected mechanisms underlie specific oncologic pathways impacting cervical cancer. Diet significantly influences the hyperactivation or inactivation of cancer-related pathways, affecting cervical cancer risk.
KEYWORDS
Cervical cancer, oncological pathway, dietary factors
Citas
Momenimovahed Z, Salehiniya H. Incidence, mortality and risk factors of cervical cancer in the world. Biomedical Research and Therapy. 2017 Dec 8;4(12):1795.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May 4;71(3):209–49.
Nisar S, Hashem S, Macha MA, Yadav SK, Muralitharan S, Therachiyil L, et al. Exploring Dysregulated Signaling Pathways in Cancer. Curr Pharm Des. 2020 Mar 18;26(4):429–45.
Campos-Parra AD, Padua-Bracho A, Pedroza-Torres A, Figueroa-González G, Fernández-Retana J, Millan-Catalan O, et al. Comprehensive transcriptome analysis identifies pathways with therapeutic potential in locally advanced cervical cancer. Gynecol Oncol. 2016 Nov;143(2):406–13.
Miranda-Galvis M, Loveless R, Kowalski LP, Teng Y. Impacts of Environmental Factors on Head and Neck Cancer Pathogenesis and Progression. Cells. 2021 Feb 13;10(2):389.
Barchitta M, Maugeri A, Quattrocchi A, Agrifoglio O, Scalisi A, Agodi A. The Association of Dietary Patterns with High-Risk Human Papillomavirus Infection and Cervical Cancer: A Cross-Sectional Study in Italy. Nutrients. 2018 Apr 11;10(4):469.
Peng X, Zhang Y, Gao J, Cai C. MiR-1258 promotes the apoptosis of cervical cancer cells by regulating the E2F1/P53 signaling pathway. Exp Mol Pathol. 2020 Jun;114:104368.
Wang Q, Wang B, Zhang W, Zhang T, Liu Q, Jiao X, et al. APLN promotes the proliferation, migration, and glycolysis of cervical cancer through the PI3K/AKT/mTOR pathway. Arch Biochem Biophys. 2024 May;755:109983.
Liu T, Chen J, Du Q, Liu J, Chen M, Ooi S, et al. Family with sequence similarity 83 member A promotes tumor cell proliferation and metastasis and predicts poor prognosis in cervical cancer. Pathol Res Pract. 2021 Jun;222:153450.
Kang C, Duo Y, Zheng L, Zhao N, Wang J, Liu Z, et al. CAFs-derived exosomes promote the development of cervical cancer by regulating miR-18a-5p-TMEM170B signaling axis. Biochem Biophys Res Commun. 2024 Jan;694:149403.
Li Q, Chen Y, Xu J, Zhu X. WITHDRAWN: LncRNA MIR497HG inhibits cervical cancer by upregulating BCL6B to block PI3K/AKT signaling. Biochem Biophys Res Commun. 2024 Feb;149727.
Zhang X, Wang M, Zhang Y, Yang J, Duan W. Knockdown of CENPU inhibits cervical cancer cell migration and stemness through the FOXM1/Wnt/β-catenin pathway. Tissue Cell. 2023 Apr;81:102009.
Meyer HJ, Gundermann P, Höhn AK, Hamerla G, Surov A. Associations between whole tumor histogram analysis parameters derived from ADC maps and expression of EGFR, VEGF, Hif 1-alpha, Her-2 and Histone 3 in uterine cervical cancer. Magn Reson Imaging. 2019 Apr;57:68–74.
Li Z, Wei R, Yao S, Meng F, Kong L. HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancer. Heliyon. 2024 Jan;10(2):e24664.
Chen Q, Tian WJ, Huang ML, Liu CH, Yao TT, Guan MM. Association Between HIF-1 Alpha Gene Polymorphisms and Response in Patients Undergoing Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer. Medical Science Monitor. 2016 Sep 5;22:3140–6.
de Almeida VH, de Melo AC, Meira DD, Pires AC, Nogueira-Rodrigues A, Pimenta-Inada HK, et al. Radiotherapy modulates expression of EGFR, ERCC1 and p53 in cervical cancer. Brazilian Journal of Medical and Biological Research. 2018;51(1).
Jiang Y, Li T, Qian Y, Zuo X, Liu J. Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway. Pain Res Manag. 2022 Apr 21;2022:1–9.
Tan B, Wikan N, Lin S, Thaklaewphan P, Potikanond S, Nimlamool W. Inhibitory actions of oxyresveratrol on the PI3K/AKT signaling cascade in cervical cancer cells. Biomedicine & Pharmacotherapy. 2024 Jan;170:115982.
Chen Y, Chen S, Chen K, Ji L, Cui S. Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways. Chin Herb Med. 2024 Jan;16(1):94–105.
Shi WJ, Liu H, Ge YF, Wu D, Tan YJ, Shen YC, et al. LINC00673 exerts oncogenic function in cervical cancer by negatively regulating miR-126-5p expression and activates PTEN/PI3K/AKT signaling pathway. Cytokine. 2020 Dec;136:155286.
Li J, Wang X, Li Z, Li M, Zheng X, Zheng D, et al. SULF1 Activates the VEGFR2/PI3K/AKT Pathway to Promote the Development of Cervical Cancer. Curr Cancer Drug Targets. 2024 Aug;24(8):820–34.
Huang J, Yang J, Zhang Y, Lu D, Dai Y. FTO promotes cervical cancer cell proliferation, colony formation, migration and invasion via the regulation of the BMP4/Hippo/YAP1/TAZ pathway. Exp Cell Res. 2023 Jun;427(1):113585.
Ma H, Han F, Yan X, Qi G, Li Y, Li R, et al. PBK promotes aggressive phenotypes of cervical cancer through ERK/c‐Myc signaling pathway. J Cell Physiol. 2021 Apr 13;236(4):2767–81.
Xu T, Zeng Y, Shi L, Yang Q, Chen Y, Wu G, et al. Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer. Journal of Experimental & Clinical Cancer Research. 2020 Dec 10;39(1):183.
Feng Y, Zhou S, Li G, Hu C, Zou W, Zhang H, et al. Nuclear factor-κB–dependent microRNA-130a upregulation promotes cervical cancer cell growth by targeting phosphatase and tensin homolog. Arch Biochem Biophys. 2016 May;598:57–65.
ZHANG W, LIU HT. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 2002 Mar;12(1):9–18.
Tilborghs S, Corthouts J, Verhoeven Y, Arias D, Rolfo C, Trinh XB, et al. The role of Nuclear Factor-kappa B signaling in human cervical cancer. Crit Rev Oncol Hematol. 2017 Dec;120:141–50.
Abudoukerimu A, Hasimu A, Abudoukerimu A, Tuerxuntuoheti G, Huang Y, Wei J, et al. HIF‐1α Regulates the Progression of Cervical Cancer by Targeting YAP/TAZ. J Oncol. 2022;2022(1):3814809.
Santinon G, Brian I, Pocaterra A, Romani P, Franzolin E, Rampazzo C, et al. dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene-induced senescence. EMBO J. 2018 Jun 12;37(11).
Zhang L, Chinnathambi A, Alharbi SA, Veeraraghavan VP, Mohan SK, Zhang G. Punicalagin promotes the apoptosis in human cervical cancer (ME-180) cells through mitochondrial pathway and by inhibiting the NF-kB signaling pathway. Saudi J Biol Sci. 2020 Apr;27(4):1100–6.
Xia L, Tan S, Zhou Y, Lin J, Wang H, Oyang L, et al. Role of the NFkB-signaling pathway in cancer. Onco Targets Ther. 2018 Apr;Volume 11:2063–73.
Bu H, Liu D, Cui J, Cai K, Shen F. Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells. Transl Cancer Res. 2019 Sep;8(5):1782–94.
Lugano R, Ramachandran M, Dimberg A. Tumor angiogenesis: causes, consequences, challenges and opportunities. Cellular and Molecular Life Sciences. 2020 May 6;77(9):1745–70.
Tomao S, Tomao F, Rossi L, Zaccarelli E, Caruso D, Zoratto F, et al. Angiogenesis and antiangiogenic agents in cervical cancer. Onco Targets Ther. 2014 Dec;2237.
Yetkin-Arik B, Kastelein AW, Klaassen I, Jansen CHJR, Latul YP, Vittori M, et al. Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2021 Jan;1875(1):188446.
Yang Q, Al-Hendy A. The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer. Cells. 2022 Mar 29;11(7):1149.
Chen L, Qing J, Xiao Y, Huang X, Chi Y, Chen Z. TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway. BMC Cancer. 2022 Apr 7;22(1):370.
Qureshi R, Arora H, Rizvi MA. EMT in cervical cancer: Its role in tumour progression and response to therapy. Cancer Lett. 2015 Jan;356(2):321–31.
Medina-Contreras O, Luvián-Morales J, Valdez-Palomares F, Flores-Cisneros L, Sánchez-López M, Soto-Lugo JH, et al. Immunonutrition in Cervical Cancer: Immune Response Modulation by Diet. Revista de investigaci�n Cl�nica. 2020 Sep 17;72(4).
Nath S, Nasrin SS, Samanta A, Nuzhad A, Ghosh P, Manna A, et al. The Effects of Dietary Nutrient Intake on Cervical Cancer: A Brief Review. Indian Journal of Medical and Paediatric Oncology. 2023 Apr 24;
Koshiyama M. The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers. Healthcare. 2019 Jul 7;7(3):88.
Ferreira M, Gomes D, Neto M, Passarinha LA, Costa D, Sousa Â. Development and Characterization of Quercetin-Loaded Delivery Systems for Increasing Its Bioavailability in Cervical Cancer Cells. Pharmaceutics. 2023 Mar 14;15(3):936.
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