ASOCIACIÓN ENTRE MEDIDAS CLÍNICAS PARA EL DIAGNÓSTICO DE OSTEOSARCOPENIA CON FUNCIONALIDAD Y MORTALIDAD EN ADULTOS MAYORES: ESTUDIO LONGITUDINAL
Osteosarcopenia, funcionalidad y mortalidad.
DOI:
https://doi.org/10.12873/423sepulvedaKeywords:
Sarcopenia, aging, functionality, mortality, body compositionAbstract
Introduction: Osteosarcopenia is a new geriatric syndrome that could negatively impact the functionality and quality of life of older adults. However, diagnostic assessments of body composition and physical function are still unclear.
Aim: To determine the association between clinical measures for the diagnosis of osteosarcopenia with functionality and mortality in independent older adults.
Materials and Methods: A longitudinal observational study with 242 older adults (age: 68 ± 6 years; women: 69%) from Londrina, Brazil. The clinical measures for the diagnosis of osteosarcopenia were fat free mass index (FFMI); appendicular lean mass (ALM); calf circumference (CC); phase angle (PA); handgrip strength (HGS) and bone mineral density (BMD). Incremental shuttle walking; test 6-minute walk text; one-legged stance test; sit-to-stand test and mortality in 5 and 9 years were assessed. Correlation and regression analysis were done.
Results: Correlations were observed between the clinical variables of osteosarcopenia with functionality (r from -0,44 to 0,36) and mortality (r from 0,17 hasta 0,26) in both sexes. The predictors of 5-year mortality were PA (HR: 0,38) and BMD (HR: 0,59) for women, and PA (HR: 0,61) for men. The 9-year mortality predictors were the PA (HR: 0,41) and BMD (HR: 0,56) for women and the CC (HR: 0,87) and (HR: 0,39) for men.
Conclusions: Clinical measures for the diagnosis of osteosarcopenia calf circumference, phase angle, bone mineral density and handgrip strength were associated with functionality and mortality at 5 and 9 years in older adults. Therefore, it should be included in the geriatric evaluation carried out by the health team.
References
Cedeno-Veloz B, López-Dóriga Bonnardeauxa P, Duque G. Osteosarcopenia: A narrative review. Revista Espanola de Geriatria y Gerontologia 2018. https://doi.org/10.1016/j.regg.2018.09.010.
Sepúlveda-Loyola W, Phu S, Bani Hassan E, Brennan-Olsen SL, Zanker J, Vogrin S, et al. The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics. J Am Med Dir Assoc 2020;21:220–5. https://doi.org/10.1016/j.jamda.2019.09.005.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age and Ageing 2019;48:16–31. https://doi.org/10.1093/ageing/afy169.
Yoo J-I, Ha Y-C. Review of Epidemiology, Diagnosis, and Treatment of Osteosarcopenia in Korea. Journal of Bone Metabolism 2018;25:1. https://doi.org/10.11005/jbm.2018.25.1.1.
Araújo de Castro L, Morita AA, Sepúlveda-Loyola W, da Silva RA, Pitta F, Krueger E, et al. Are there differences in muscular activation to maintain balance between individuals with chronic obstructive pulmonary disease and controls? Respiratory Medicine 2020;173:106016. https://doi.org/10.1016/j.rmed.2020.106016.
Sepúlveda-Loyola W, Osadnik C, Phu S, Morita AA, Duque G, Probst VS. Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis. Journal of Cachexia, Sarcopenia and Muscle 2020;11:1164–76. https://doi.org/10.1002/jcsm.12600.
World Health Organization. WHO scientific group on the assessment of osteoporosis at primary health care level. 2007.
García-García FJ, Carcaillon L, Fernandez-Tresguerres J, Alfaro A, Larrion JL, Castillo C, et al. A New Operational Definition of Frailty: The Frailty Trait Scale. J Am Med Dir Assoc 2014;15:371.e7-371.e13. https://doi.org/10.1016/j.jamda.2014.01.004.
Vandenbroucke JP, Von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. Epidemiology 2007;18:805–35. https://doi.org/10.1097/EDE.0b013e3181577511.
Molari M, Fernandes KBP, Marquez A de S, Probst VS, Bignardi PR, Teixeira D de C. Impact of physical and functional fitness on mortality from all causes of physically independent older adults. Archives of Gerontology and Geriatrics 2021;97:104524. https://doi.org/10.1016/j.archger.2021.104524.
Lennon J, Lima M. 4- Resenha de Livro Dimensões Físicas do Envelhecimento – Waneen W . Spirduso , 2005 2013;4:57–76.
Bertolucci PHF, Brucki SMD, Campacci SR, Juliano Y. O Mini-Exame do Estado Mental em uma população geral: impacto da escolaridade. Arquivos de Neuro-Psiquiatria 1994;52:01–7. https://doi.org/10.1590/s0004-282x1994000100001.
Da Silva Ricardo et al. Asociación del ángulo de fase con parámetros de evaluación del estado nutricional en pacientes en hemodiálisis. Rev Chil Nutr 2019;46:99–106.
Sánchez-Castellano C, Martín-Aragón S, Vaquero-Pinto N, Bermejo-Bescós P, Merello de Miguel A, Cruz-Jentoft A-J. Prevalencia de sarcopenia y características de los sarcopénicos en pacientes mayores de 80 años ingresados por fractura de cadera. Nutrición Hospitalaria 2019. https://doi.org/10.20960/nh.02607.
Hamad B, Basaran S, Coskun Benlidayi I. Osteosarcopenia among postmenopausal women and handgrip strength as a practical method for predicting the risk. Aging Clinical and Experimental Research 2020;32:1923–30. https://doi.org/10.1007/s40520-019-01399-w.
Probst VS, Hernandes NA, Teixeira DC, Felcar JM, Mesquita RB, Gonalves CG, et al. Reference values for the incremental shuttle walking test. Respiratory Medicine 2012;106:243–8. https://doi.org/10.1016/j.rmed.2011.07.023.
Britto RR, Probst VS, Dornelas De Andrade AF, Samora GAR, Hernandes NA, Marinho PEM, et al. Reference equations for the six-minute walk distance based on a Brazilian multicenter study. Brazilian Journal of Physical Therapy 2013;17:556–63. https://doi.org/10.1590/S1413-35552012005000122.
Tiedemann A, Shimada H, Sherrington C, Murray S, Lord S. The comparative ability of eight functional mobility tests for predicting falls in community-dwelling older people. Age and Ageing 2008;37:430–5. https://doi.org/10.1093/ageing/afn100.
Stanton WJ. from the SAGE Social Science Collections . All Rights. Hispanic Journal of Behavioral Sciences 1987;9:183–205.
Hsu K, Liao C, Tsai M, Chen C. Effects of Exercise and Nutritional Intervention on Body Composition , Metabolic Health , and Physical Performance in Adults with Sarcopenic Obesity : A 2019.
Matias CN, Nunes CL, Francisco S, Tomeleri CM, Cyrino ES, Sardinha LB, et al. Phase angle predicts physical function in older adults. Archives of Gerontology and Geriatrics 2020;90:104151. https://doi.org/10.1016/j.archger.2020.104151.
Arroyo P, Lera L, Sánchez H, Bunout D, Luis J, Albala C. composición corporal y limitaciones funcionales en ancianos 2007:846–54.
Hsu K, Liao C, Tsai M, Chen C. Effects of Exercise and Nutritional Intervention on Body Composition , Metabolic Health , and Physical Performance in Adults with Sarcopenic Obesity : A 2019.
Garlini LM, Alves FD, Ceretta LB, Perry IS, Souza GC, Clausell NO. Phase angle and mortality: a systematic review. European Journal of Clinical Nutrition 2019;73:495–508. https://doi.org/10.1038/s41430-018-0159-1.
Matias CN, Nunes CL, Francisco S, Tomeleri CM, Cyrino ES, Sardinha LB, et al. Phase angle predicts physical function in older adults. Archives of Gerontology and Geriatrics 2020;90:104151. https://doi.org/10.1016/j.archger.2020.104151.
Drey M, Sieber CC, Bertsch T, Bauer JM, Schmidmaier R, Group TF intervention, et al. Osteosarcopenia is more than sarcopenia and osteopenia alone. Aging Clinical and Experimental Research 2016;28:895–899.
Tomeleri CM, Cavalcante EF, Antunes M, Nabuco HCG, De Souza MF, Teixeira DC, et al. Phase Angle Is Moderately Associated With Muscle Quality and Functional Capacity, Independent of Age and Body Composition in Older Women. Journal of Geriatric Physical Therapy 2019;42:281–6. https://doi.org/10.1519/JPT.0000000000000161.
Easton JF, Stephens CR, Román-Sicilia H, Cesari M, Pérez-Zepeda MU. Anthropometric measurements and mortality in frail older adults. Experimental Gerontology 2018;110:61–6. https://doi.org/10.1016/j.exger.2018.05.011.
Salech F, Marquez C, Lera L, Angel B, Saguez R, Albala C. Osteosarcopenia Predicts Falls, Fractures, and Mortality in Chilean Community-Dwelling Older Adults. J Am Med Dir Assoc 2020:1–6. https://doi.org/10.1016/j.jamda.2020.07.032.
Iseri K, Dai L, Chen Z, Qureshi AR, Brismar TB, Stenvinkel P, et al. Bone mineral density and mortality in end-stage renal disease patients 2020;13:307–21. https://doi.org/10.1093/ckj/sfaa089.
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