Analysis of nutritional status in older adult patients hospitalized for COVID-19 in intensive care units, Perú, 2020

Authors

  • Aili Fernández Yóplac Escuela de Nutrición Humana, Universidad Peruana Unión, Lima, Perú
  • Sergio E. Calizaya-Milla Escuela de Nutrición Humana, Universidad Peruana Unión, Lima, Perú
  • Sandra P. Carranza-Cubas Escuela de Medicina Humana, Universidad Señor de Sipán, Chiclayo, Perú https://orcid.org/0000-0002-7535-3148
  • Jacksaint Saintila Escuela de Medicina Humana, Universidad Señor de Sipán, Chiclayo, Perú https://orcid.org/0000-0002-7340-7974
  • Yaquelin E. Calizaya-Milla Escuela de Nutrición Humana, Universidad Peruana Unión, Lima, Perú https://orcid.org/0000-0002-0170-6131

DOI:

https://doi.org/10.12873/441fernandez

Keywords:

COVID-19, Malnutrition, Anemia, Body Weight, Intensive Care Units

Abstract

Background: Nutritional status is an indicator of health status and an element of the body's resistance to intercurrent diseases, including COVID-19. Objective: To analyze the nutritional status in hospitalized older adult ICU patients diagnosed with COVID-19. Methods: A cross-sectional study was conducted between April and May 2020. The nutritional status of a group of 83 older adult patients with COVID-19 was determined and compared. The data were analyzed using Chi-square and t-student tests, considering a significance level of 5%. Results: Approximately 42.2% of the patients had excess body weight. Anemia (46.9% vs. 9.8%, p < 0.001) and risk of sarcopenia (45.7% vs. 33.3%, p = 0.011) were higher in women compared to men presenting COVID-19. Furthermore, urea levels were significantly lower in patients with malnutrition compared to those without malnutrition (37.9 mg/dL vs. 44.1 mg/dL, p = 0.020). Similarly, leukocyte concentration was found to be lower in COVID-19 patients with malnutrition 9.6 WBC (x10g ^g/L), p = 0.002. Finally, c-reactive protein (CRP) (37.9 mg/L, p = 0.015), oxaloacetic transaminase (OGT) (61.08 U/L, p = 0.045) and pyruvic transaminase (PGR) (37.14 U/L, p = 0.030) levels were significantly higher in patients with malnutrition compared to those without malnutrition. Conclusion: Nutritional status has a considerable effect on the clinical outcomes of patients with COVID-19. Therefore, further nutritional interventions should be implemented in this regard, paying special attention to both the elderly population.

References

Guo Y-R, Cao Q-D, Hong Z-S, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res 2020; 7: 11. DOI: https://doi.org/10.1186/s40779-020-00240-0

Silverio R, Gonçalves DC, Andrade MF, et al. Coronavirus Disease 2019 (COVID-19) and Nutritional Status: The Missing Link? Adv Nutr 2021; 12: 682–692. DOI: https://doi.org/10.1093/advances/nmaa125

Cascella M, Rajnik M, Cuomo A, et al. Features, Evaluation and Treatment Coronavirus (COVID-19). Treasure Island (FL): StatPearls Publishing, http://www.ncbi.nlm.nih.gov/pubmed/32150360 (2020, accessed 14 September 2021).

Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis. Int J Infect Dis 2020; 94: 91–95. DOI: https://doi.org/10.1016/j.ijid.2020.03.017

MI C, DL W. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr 2003; 22: 235–239. DOI: https://doi.org/10.1016/S0261-5614(02)00215-7

Shpata V, Ohri I, Nurka T, et al. The prevalence and consequences of malnutrition risk in elderly Albanian intensive care unit patients. Clin Interv Aging 2015; 10: 481–486.

PM S, SJ P, Y C, et al. Utilizing multiple methods to classify malnutrition among elderly patients admitted to the medical and surgical intensive care units (ICU). Clin Nutr 2013; 32: 752–757. DOI: https://doi.org/10.1016/j.clnu.2012.12.012

Shpata V, Ohri I, Nurka T, et al. The prevalence and consequences of malnutrition risk in elderly Albanian intensive care unit patients. Clin Interv Aging 2015; 10: 481. DOI: https://doi.org/10.2147/CIA.S77042

Guillin OM, Vindry C, Ohlmann T, et al. Selenium, Selenoproteins and Viral Infection. Nutrients; 11. Epub ahead of print 1 September 2019. DOI: 10.3390/NU11092101. DOI: https://doi.org/10.3390/nu11092101

Marasco G, Serenari M, Renzulli M, et al. Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments. J Gastroenterol 2020; 55: 927–943. DOI: https://doi.org/10.1007/s00535-020-01711-w

Cunha LL, Perazzio SF, Azzi J, et al. Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response. Front Immunol 2020; 11: 1748. DOI: https://doi.org/10.3389/fimmu.2020.01748

R V-R, BE M-C, II A-G, et al. Diet, exercise and gut mucosal immunity. Proc Nutr Soc 2010; 69: 644–650. DOI: https://doi.org/10.1017/S0029665110002533

Abadía Otero J, Briongos Figuero LS, Gabella Mattín M, et al. The nutritional status of the elderly patient infected with COVID-19: the forgotten risk factor? Curr Med Res Opin 2021; 37: 549–554. DOI: https://doi.org/10.1080/03007995.2021.1882414

Recinella G, Marasco G, Serafini G, et al. Prognostic role of nutritional status in elderly patients hospitalized for COVID-19: a monocentric study. Aging Clin Exp Res 2020; 32: 2695. DOI: https://doi.org/10.1007/s40520-020-01727-5

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507–513. DOI: https://doi.org/10.1016/S0140-6736(20)30211-7

Giacalone D, Frøst MB, Rodríguez-Pérez C. Reported Changes in Dietary Habits During the COVID-19 Lockdown in the Danish Population: The Danish COVIDiet Study. Front Nutr 2020; 7: 592112. DOI: https://doi.org/10.3389/fnut.2020.592112

Peña YO. Insatisfacción de la imagen corporal y autoestima en estudiantes de secundaria hablantes y no hablantes de lengua indígena. Rev Esp Nutr Comunitaria; 27.

Schwingshackl L, Morze J, Hoffmann G. Mediterranean diet and health status: Active ingredients and pharmacological mechanisms. Br J Pharmacol 2020; 177: 1241–1257. DOI: https://doi.org/10.1111/bph.14778

Gili R, Leeson S, Montes-Chañi E, et al. Healthy Vegan Lifestyle Habits among Argentinian Vegetarians and Non-Vegetarians. Nutrients 2019; 11: 154. DOI: https://doi.org/10.3390/nu11010154

Mohammad S, Aziz R, Al Mahri S, et al. Obesity and COVID-19: what makes obese host so vulnerable? Immun Ageing; 18. Epub ahead of print 1 December 2021. DOI: 10.1186/S12979-020-00212-X. DOI: https://doi.org/10.1186/s12979-020-00212-x

Simonnet A, Chetboun M, Poissy J, et al. High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) Requiring Invasive Mechanical Ventilation. Obesity 2020; 28: 1195–1199. DOI: https://doi.org/10.1002/oby.22831

Lighter J, Phillips M, Hochman S, et al. Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clinical Infectious Diseases 2020; 71: 896–897. DOI: https://doi.org/10.1093/cid/ciaa415

Rottoli M, Bernante P, Belvedere A, et al. How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre. Eur J Endocrinol 2020; 183: 389–397. DOI: https://doi.org/10.1530/EJE-20-0541

Tao Z, Xu J, Chen W, et al. Anemia is associated with severe illness in COVID‐19: A retrospective cohort study. J Med Virol 2021; 93: 1478–1488. DOI: https://doi.org/10.1002/jmv.26444

Bergamaschi G, Borrelli de Andreis F, Aronico N, et al. Anemia in patients with Covid-19: pathogenesis and clinical significance. Clin Exp Med 2021; 21: 239. DOI: https://doi.org/10.1007/s10238-021-00699-8

Zhou M, Qi J, Li X, et al. The proportion of patients with thrombocytopenia in three human-susceptible coronavirus infections: a systematic review and meta-analysis. Br J Haematol 2020; 189: 438–441. DOI: https://doi.org/10.1111/bjh.16655

Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England) 2020; 395: 497. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5

Wang C, Deng R, Gou L, et al. Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters. Ann Transl Med 2020; 8: 593–593. DOI: https://doi.org/10.21037/atm-20-3391

Küçükceran K, Ayrancı MK, Girişgin AS, et al. The role of the BUN/albumin ratio in predicting mortality in COVID-19 patients in the emergency department. Am J Emerg Med 2021; 48: 33–37. DOI: https://doi.org/10.1016/j.ajem.2021.03.090

Rodrigues HCN, Silva ML, Mantovani M dos S, et al. Higher urea-to-albumin ratio is associated with mortality risk in critically ill COVID-19 patients. Clin Nutr ESPEN 2023; 56: 9–12. DOI: https://doi.org/10.1016/j.clnesp.2023.04.017

Wei C, Liu Y, Li Y, et al. Evaluation of the nutritional status in patients with COVID-19. J Clin Biochem Nutr 2020; 67: 116. DOI: https://doi.org/10.3164/jcbn.20-91

Kashtanova DA, Erema V V., Gusakova MS, et al. Mortality and survival in nonagenarians during the COVID-19 pandemic: Unstable equilibrium of aging. Front Med 2023; 10: 1132476. DOI: https://doi.org/10.3389/fmed.2023.1132476

Li T, Zhang Y, Gong C, et al. Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China. Eur J Clin Nutr 2020; 74: 871–875. DOI: https://doi.org/10.1038/s41430-020-0642-3

shabanpur M, Pourmahmoudi A, Nicolau J, et al. The importance of nutritional status on clinical outcomes among both ICU and Non-ICU patients with COVID-19. Clin Nutr ESPEN 2022; 49: 225–231. DOI: https://doi.org/10.1016/j.clnesp.2022.04.016

Cai Q, Huang D, Yu H, et al. COVID-19: Abnormal liver function tests. J Hepatol 2020; 73: 566–574. DOI: https://doi.org/10.1016/j.jhep.2020.04.006

Gan Q, Gong B, Sun M, et al. A High Percentage of Patients Recovered From COVID-19 but Discharged With Abnormal Liver Function Tests. Front Physiol 2021; 12: 642922. DOI: https://doi.org/10.3389/fphys.2021.642922

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Published

2024-01-02

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[1]
2024. Analysis of nutritional status in older adult patients hospitalized for COVID-19 in intensive care units, Perú, 2020. Nutrición Clínica y Dietética Hospitalaria. 44, 1 (Jan. 2024). DOI:https://doi.org/10.12873/441fernandez.

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